家族史与肥胖对2型糖尿病协同作用

目的探讨糖尿病家族史与肥胖在2型糖尿病发病中的协同作用。方法以450例2型糖尿病患者为病例组3,158名血糖正常者为对照组,运用相加模型分析糖尿病家族史与肥胖对2型糖尿病的交互作用。结果糖尿病家族史与肥胖对2型糖尿病的发病有协同作用,协同效应指数为1.655;交互效应超额相对危险度为0.834;纯因子归因交互效应百分比为39.58%;用多因素Logistic回归模型调整年龄、性别、高血压、体力活动、经济收入、学历等影响因素后,协同效应指数为1.710;交互效应超额相对危险度为1.047;纯因子归因交互效应百分比为41.51%。结论糖尿病家族史与肥胖同时存在可增加患2型糖尿病的危险性。

Synergistic effect of diabetes family history and obesity on incidence of type 2 diabetes

Objective To explore the synergistic effect of diabetes family history and obesity on the incidence of type 2 diabetes.Methods Totally 450 type 2 diabetes patients were appointed as case group and 3 158 people with normal blood glucose were appointed as control group.The interaction between diabetes family history and obesity was analysed with an additive model.Results There was a synergistic effect between diabetes family history and obesity on the incidence of type 2 diabetes.The synergy index was 1.655.The relative excess risk due to interaction was 0.834 and the pure attributable interaction percent was 39.58%.After adjusting for age,gender,hypertension,physical activity,income,and education by multiple logistic regression,the synergy index was 1.710;the relative excess risk due to interaction was 1.047;pure attributable interaction percent was 41.51%.Conclusion Individuals with both diabetes family history and obesity have a higher risk of type 2 diabetes compared to those exposed to only one factor.