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Simultaneous noninvasive evaluation of gastric emptying and orocaecal transit times |
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| Authors: | J. F. Bergmann O. Chassany P. J. Guillausseau M. Bayle S. Chagnon C. Caulin J. R. Sallenave |
| Affiliation: | (1) Unité de Recherches Thérapeutiques, Hôpital Lariboisière, 2 rue Ambroise Paré, F-75010 Paris, France;(2) Department of Endocrinology, Lariboisière Hospital, 2 rue Ambroise Paré, F-75010 Paris, France;(3) Department of Pharmacy, Lariboisière Hospital, 2 rue Ambroise Paré, F-75010 Paris, France;(4) Department of Radiology, Lariboisière Hospital, 2 rue Ambroise Paré, F-75010 Paris, France;(5) Janssen Laboratories, Boulogne Billancourt, France |
| Abstract: | Summary The aim of the study was to use a novel combination of two methods for the simultaneous evaluation of two effects of oral cisapride in 10 diabetic patients with autonomic neuropathy; gastric emptying time was measured by following radio-opaque markers and orocaecal transit time by the sulphasalazine-sulphapridine method. The study was of double-blind, randomized, placebo-controlled, cross-over design.It was possible to evaluate the effect of a prokinetic drug on gastric emptying and orocaecal transit times using these two noninvasive techniques at the same time. Cisapride significantly reduced both the gastric emptying (1.2 h versus 2.1 h) and orocaecal tansit (5.9 h versus 7.7 h) times. |
| Keywords: | Cisapride Diabetic neuropathy gastric emptying orocaecal transit time gastroparesis controlled trial |
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