Triethyl tin does not induce intramyelinic vacuoles in the CNS of the quaking mouse |
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Authors: | Hitoshi Nagara Kinuko Suzuki Carol W. Tiffany Kunihiko Suzuki |
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Affiliation: | Department of Pathology (Neuropathology), Neuroscience and the Saul R. Korey Department of Neurology, and the Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, N.Y. 10461 (U.S.A.) |
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Abstract: | Intraperitoneal injection of triethyl tin (TET) sulfate, 5 or 10 mg/kg body weight did not induce intramyelinic edema without altering water content in quaking mice while in C5BL/6J and littermate control mice, water content was increased and typical intramyelinic edema was induced following TET injection. Even among control mice, however, there were some strain differences in the histological severity of the edema, which were in precise agreement with the quantitative alterations in water content. These observations suggest that CNS myelin in quaking may differ qualitatively from that in controls and the mode of response to TET is under genetic control. |
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Keywords: | quaking mouse triethyl tin myelin edema |
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