基于隐结构法的寻常型银屑病常见证候要素的研究

目的运用隐结构法提取寻常型银屑病常见证候要素及其对应症状。方法用统一制定的临床信息采集表收集寻常型银屑病患者的症状信息,建立数据库并进行数据的录入与预处理,用隐结构法分析数据,并结合中医专业知识对获得的隐结构模型进行诠释。结果寻常型银屑病隐结构模型中共计有43个隐变量和111个隐类,经结合专业知识诠释,初步获取寻常型银屑病涉及的病位类证候要素为:血分、肝、肾、脾,病性类证候要素为:血热、血瘀、血虚、血燥、阳虚、气虚、阴虚、湿、火(热)。结论通过隐结构法分析寻常型银屑病的前瞻性无监督数据发现,隐结构法的模型构建与中医理论有相似之处,且比有监督的数据分析有更好的客观性。本研究为进一步建立寻常型银屑病的症候诊断标准提供了依据。

Research of the normal syndrome element of psoriasis vulgaris by latent structure theory

Objective To find out the normal syndrome elements and symptoms of psoriasis vulgaris by using latent structure theory. Methods The symptoms of psoriasis vulgaris patients were collected by a uniform form, psoriasis vulgaris database was established and the data were copied into the database. The data were analyzed by constructing a Psoriasis Vulgaris latent structure model, and the results were explained by professional knowledge of Chinese Medicine. Results The latent structure model of psoriasis vulgaris had 43 latent variables and 111 latent categories. By using the Chinese medicine theory, it was concluded that the syndrome-elements of location of psoriasis vulgaris were: blood, liver, kidney, and spleen; the syndrome-elements of nature of disease of psoriasis vulgaris were: heat of blood, blood stasis, blood deficiency, dry because of blood deficiency, yang deficiency, qi deficiency, yin deficiency, dampness and heat. Conclusion The research used latent structure to analyze the data by no supervising, found latent structure is similar to the Chinese medicine theory. It is more objective and is a good way to do the syndrome standard research work. The research gave some support to establish standard for syndrome diagnosis of psoriasis vulgaris.