| 生脉注射液中高异黄酮类成分研究 |
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| 引用本文： | 汪祺,刘燕,郑笑为,于健东,戴忠,鲁静,林瑞超. 生脉注射液中高异黄酮类成分研究[J]. 中国药学杂志, 2012, 47(19): 1539-1541 |
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| 作者姓名： | 汪祺 刘燕 郑笑为 于健东 戴忠 鲁静 林瑞超 |
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| 作者单位： | 中国食品药品检定研究院中药民族药检定所，北京 100050 |
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| 摘 要： | 目的 探讨生脉注射液中高异黄酮类成分物质基础。方法 以麦冬萃取物化学成分研究为基础，采用液相色谱-质谱联用技术对8家生产企业的生脉注射液样品进行化学成分指认。结果 麦冬萃取物中8个主要化学成分中8家生产企业多数共有成分为麦冬黄酮B，麦冬黄烷酮B，麦冬黄烷酮A，甲基麦冬黄烷酮A，甲基麦冬黄烷酮B。结论 建立了生脉注射液中高异黄酮类成分的检查方法，为研究注射剂高异黄酮类成分及统一制法提供实验依据。
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| 关 键 词： | 生脉注射液 麦冬 离子阱质谱 高异黄酮 麦冬黄酮B 麦冬黄烷酮B |
| 收稿时间： | 2011-12-12; |
Study on Homoisoflavones in Shengmai Injection |
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| WANG Qi,LIU Yan,ZHENG Xiao-wei,YU Jian-dong,DAI Zhong,LU Jing,LING Rui-chao. Study on Homoisoflavones in Shengmai Injection[J]. Chinese Pharmaceutical Journal, 2012, 47(19): 1539-1541 |
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| Authors: | WANG Qi LIU Yan ZHENG Xiao-wei YU Jian-dong DAI Zhong LU Jing LING Rui-chao |
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| Affiliation: | National Institutes for Food and Drug Control， Beijing 100050， China |
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| Abstract: | OBJECTIVE To investigate the composition of homoisoflavones in Shengmai injection. METHODS On the basis of studies on the chemical constituents of Ophiopogonis Radix extract， the chemical constituents in Shengmai injection from eight enterprises were identified by LC-MS. RESULTS Ophiopogonone B， ophiopogonanone B， ophiopogonanone A， methylophiopogonanone A， and methylophiopogonanone B were the common components among the eight identified constituents in Ophiopogonis Radix extract. CONCLUSION The analytical method for homoisoflavones in Shengmai injection is established， which can be used as the basis for further study and quality control. |
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| Keywords: | Shengmai injection Ophiopogonis Radix Ion Trap LC/MS homoisoflavone ophiopogonone B ophiopogonanone B |
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