| 脑内高表达microRNAs的时空效应及其在神经管缺陷中的可能作用 |
| |
| 引用本文： | 白宝玲,李会莉,陈淑媛,王晓蕾,张勤,赵慧智,张霆.脑内高表达microRNAs的时空效应及其在神经管缺陷中的可能作用[J].中国病理生理杂志,2012,28(12):2291-2296. |
| |
| 作者姓名： | 白宝玲 李会莉 陈淑媛 王晓蕾 张勤 赵慧智 张霆 |
| |
| 作者单位： | 首都儿科研究所，北京 100020 |
| |
| 基金项目： | 国家自然科学基金资助项目（No. 31071133）；北京市科委科技新星资助项目（No. 2010B045） |
| |
| 摘 要： |
|
| 关 键 词： | 微小RNA 神经管缺陷 哺乳动物 |
| 收稿时间： | 2012-05-25 |
Temporal and spatioal effects of enriched miRNAs in brain and possible role in neural tube defects |
| |
| BAI Bao-ling,LI Hui-li,CHEN Shu-yuan,WANG Xiao-lei,ZHANG Qin,ZHAO Hui-zhi,ZHANG Ting.Temporal and spatioal effects of enriched miRNAs in brain and possible role in neural tube defects[J].Chinese Journal of Pathophysiology,2012,28(12):2291-2296. |
| |
| Authors: | BAI Bao-ling LI Hui-li CHEN Shu-yuan WANG Xiao-lei ZHANG Qin ZHAO Hui-zhi ZHANG Ting |
| |
| Institution: | Capital Institute of Pediatrics, Beijing 100020, China. |
| |
| Abstract: | MicroRNAs (miRNAs) are known to play an important role in regulating the cell proliferation, differentiation and organogenesis. Abnormal expression of miRNAs is associated with increased risk for various diseases, such as neural tube defects (NTD), which is a severe developmental disease as the result of closing the neural tube incompletely or too early. The present review summarizes some enriched miRNAs in the brain of mammals and their spatial temporal feature, and tries to elaborate the relationship between the aberrant expression of miRNAs and the pathogenesis of NTD. |
| |
| Keywords: | MicroRNA Neural tube defects Mammals |
|
| 点击此处可从《中国病理生理杂志》浏览原始摘要信息 |
| 点击此处可从《中国病理生理杂志》下载免费的PDF全文 |
