| 南海橙色手指海绵化学成分研究 |
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| 引用本文： | 许文杰,华怀杰,郑加林,廖小建,徐石海.南海橙色手指海绵化学成分研究[J].中国药学杂志,2012,47(22):1799-1801. |
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| 作者姓名： | 许文杰 华怀杰 郑加林 廖小建 徐石海 |
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| 作者单位： | 1.深圳信立泰药业股份有限公司,广东 深圳 361021;2.暨南大学化学系, 广州 510632 |
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| 基金项目： | 国家自然科学基金资助项目（21172094）;广东省重大科技专项（2011A080504007） |
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| 摘 要： | 目的 研究橙色手指海绵(Axinella sp.)的化学成分。方法 采用硅胶柱色谱、Sephadex LH-20和反相半制备HPLC等方法分离化合物,根据波谱数据确定其结构。结果 从橙色手指海绵分离得到10个化合物,鉴定为：cyclo-(Val-Pro)（1)、cyclo-(Tyr-Pro)（2)、cyclo-(Phe-Pro)（3)、cyclo-(Leu-Pro)（4)、cyclo-(Ile-Pro)（5)、2′-deoxyinosine（6)、2′-deoxyadenosine（7)、spongothymidine （8）、spongouridine （9）、2′-deoxyuridine（10）。结论 所有化合物为首次从橙色手指海绵中分离得到。
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| 关 键 词： | 海绵 橙色手指海绵 结构鉴定 spongothymidine spongouridine 2′-deoxyuridine |
| 收稿时间： | 2011-02-21; |
Chemical Constituents of Axinella sp. from the South China Sea |
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| XU Wen-jie,HUA Huai-jie,ZHENG Jia-lin,LIAO Xiao-jian,XU Shi-hai.Chemical Constituents of Axinella sp. from the South China Sea[J].Chinese Pharmaceutical Journal,2012,47(22):1799-1801. |
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| Authors: | XU Wen-jie HUA Huai-jie ZHENG Jia-lin LIAO Xiao-jian XU Shi-hai |
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| Abstract: | OBJECTIVE To study the chemical constituents of Axinella sp. from the South China Sea. METHODS The compounds were isolated and purified by silica gel, Sephadex LH-20, and semi-preparative reverse-phase HPLC（C18). Their structures were identified by their spectral data. RESULTS Ten compounds were isolated from Axinella sp.and their structures were identified as cyclo-(Val-Pro)（1), cyclo-(Tyr-Pro)（2), cyclo-(Phe-Pro)（3), cyclo-(Leu-Pro)（4), cyclo-(Ile-Pro)（5), 2′-deoxyinosine（6), 2′-deoxyadenosine（7), spongothymidine （8）, spongouridine （9）and 2′-deoxyuridine （10）. CONCLUSION All the compounds were isolated from Callyspongia sp. for the first time. |
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| Keywords: | marine sponge Axinella sp Axinella sp" target="_blank">')" href="#"> Axinella sp structure elucidation spongothymidine spongouridine 2&prime -deoxyuridine |
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