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VEGF表达在涎腺腺样囊性癌中的意义
引用本文:李晓光,于肖鹏,卢会青,王延秀. VEGF表达在涎腺腺样囊性癌中的意义[J]. 口腔医学研究, 2011, 27(6): 501-503,507
作者姓名:李晓光  于肖鹏  卢会青  王延秀
作者单位:1. 泰安市中心医院口腔科,山东,泰安,271000
2. 泰安市中心医院手术室
3. 泰安市中心医院麻醉科
摘    要:目的:研究血管内皮生长因子(vascular endothelial growth factor,VEGF)在涎腺腺样囊性癌中的表达,探讨其与临床病理因素的关系。方法:采用SABC免疫组织化学染色方法检测32例涎腺腺样囊性癌(salivary ade-noid eystic carcinoma,SACC)中VEGF的表达和病灶微血管密度(microvessel density,MVD)记数,采用SPSS13.0软件行统计分析。结果:62.5%SACC组织呈VEGF阳性表达。VEGF表达阳性的SACC组织MVD显著高于VEGF表达阴性者(P〈0.05)。VEGF表达与肿瘤病理类型、淋巴结转移、肿瘤部位及临床分期密切相关。结论:VEGF是SACC主要的新生血管诱导因子之一,可促进SACC的血管生成,VEGF可做为SACC预后的一个有效指标,用于识别高危转移和不良预后者。

关 键 词:涎腺腺样囊性癌  血管内皮生长因子  肿瘤微血管密度

Significance of VEGF Expression in Salivary Adenoid Cystic Carcinoma
LI Xiao-guang,YU Xiao-peng,LU Hui-qing,et al.. Significance of VEGF Expression in Salivary Adenoid Cystic Carcinoma[J]. Journal of Oral Science Research, 2011, 27(6): 501-503,507
Authors:LI Xiao-guang  YU Xiao-peng  LU Hui-qing  et al.
Affiliation:LI Xiao-guang,YU Xiao-peng,LU Hui-qing,et al.Department of Stomatology,Taian City Central Hospital,Taian 271000
Abstract:Objective: To evaluate the clinical significance of vascular endothelial growth factor(VEGF) expression in salivary adenoid cystic carcinoma(SACC).Methods: Immunohistochemical staining(SP) was used to quantify VEGF and CD34 expression in specimens from 32 patients with SACC.SPSS13.0 statistical software was used.Results: VEGF expression was observed in 20 of the patients(62.5%).The microvessel count was significantly higher(P<0.05) in the SACC with VEGF expression than in the SACC without it.In the clinicop...
Keywords:Salivary adenoid eystic carcinoma Vascular endothelial growth factor Microvessel density  
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