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| 利培酮口服液与奥氮平治疗40例精神分裂症疗效对照 | |
| 引用本文： | 徐静文. 利培酮口服液与奥氮平治疗40例精神分裂症疗效对照[J]. 中国民康医学, 2011, 23(11): 1358-1360. DOI: 10.3969/j.issn.1672-0369.2011.11.020 |
| 作者姓名： | 徐静文 |
| 作者单位： | 上海市民政第三精神卫生中心,上海,200435 |
| 摘 要： | 目的:研究利培酮口服液与奥氮平对精神分裂症患者的疗效及意义。方法:将40例精神分裂症患者随机分为两组,各20例。研究组口服利培酮口服液治疗,对照组口服奥氮平治疗,疗程为12周。于治疗前、治疗4周末、治疗8周末、治疗12周末分别采用阳性和阴性症状评定量表(PANSS)评定临床疗效,日常生活能力量表(ADL)评定日常生活能力,药物不良反应量表(TESS)及辅助检查结果来评定药物不良反应。结果:治疗12周末,利培酮口服液组的显效率为45%,有效率为100%;奥氮平组的显效率为25%,有效率为95%;两组显效率和有效率比较,无显著性差异(P>0.05)。但在各因子减分比较上,阳性症状减分、阴性症状减分的差异性不明显(P>0.05),一般病理减分的差异性明显(P<0.05)。两种药物对患者的日常生活能力的影响均有改善效果,但两组比较,无显著性差异(P>0.05)。利培酮口服液组不良反应发生率为10%,奥氮平组不良反应发生率为15%,两组无显著性差异(P>0.05)。结论:利培酮口服液与奥氮平对精神分裂症的总体疗效相当,但利培酮口服液更适合合并糖尿病的精神分裂症患者。 |
| 关 键 词： | 精神分裂症 利培酮口服液 奥氮平 疗效 |
Efficacy Comparison of Resperidone and Olanzapine in the Treatment of Schizophrenia |
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| XU Jing-wen. Efficacy Comparison of Resperidone and Olanzapine in the Treatment of Schizophrenia[J]. medical journal of chinese peoples health, 2011, 23(11): 1358-1360. DOI: 10.3969/j.issn.1672-0369.2011.11.020 | |
| Authors: | XU Jing-wen |
| Affiliation: | XU Jing-wen(The 3rd Mental Health Center affiliated to Shanghai Civil Affairs Department,Shanghai,200435,China) |
| Abstract: | Objective:To compare the efficacy of Resperidone and Olanzapine in the treatment of schizophrenia.Methods:40 patients with schizophrenia were stochastic allocated to 2 groups treated with Resperidone and Olanzapine respectively for 12 weeks,20 patients in each group.The Positive and Negative Syndrome Scale(PANSS) was used to evaluate the clinical effect,Activities of Daily Living scale(ADL) to evaluate the daily life management,Treatment Emergent Side-effect Scale(TESS) and supplemental check to evaluate th... |
| Keywords: | Schizophrenia Resperidone Olanzapine Efficacy |
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