柴胡加龙骨牡蛎汤加减联合太极拳运动治疗抑郁症40例临床观察

目的:观察柴胡加龙骨牡蛎汤加减联合太极拳运动治疗肝气阻滞兼痰热型抑郁症的临床疗效。方法:将80例肝气阻滞兼痰热型抑郁症患者随机分为治疗组和对照组,每组各40例。治疗组给予柴胡加龙骨牡蛎汤加减联合太极拳运动治疗,对照组给予盐酸帕罗西汀治疗。2组疗程均为6周。观察患者的综合疗效及抑郁自评量表(SDS)评分、汉密尔顿抑郁量表(HAMD)评分、中医证候评分、不良反应量表(TESS)评分。结果:治疗组脱落1例,对照组脱落2例。综合疗效总有效率治疗组为94.87%(37/39),对照组为81.58%(31/38),2组比较,差异有统计学意义(P<0.05);2组治疗2、4、6周后SDS、HAMD及中医证候评分均低于治疗前(P<0.01),且治疗组治疗后各时间节点的SDS、HAMD、TESS及中医证候评分均低于对照组(P<0.05或P<0.01)。结论:柴胡加龙骨牡蛎汤加减联合太极拳运动治疗肝气阻滞兼痰热型抑郁症疗效确切,且无明显不良反应,值得临床推广应用。

Clinical effect of modified Chaihu Longgu Muli decoction combined with Tai Chi exercise in treatment of depression:An analysis of 40 cases

Objective:To investigate the clinical effect of modified Chaihu Longgu Muli decoction combined with Tai Chi exercise in the treatment of depression with liver Qi stagnation and phlegm-heat.Methods:A total of 80 patients with depression with liver Qi stagnation and phlegm-heat were randomly divided into treatment group and control group,with 40 patients in each group.The patients in the treatment group were given modified Chaihu Longgu Muli decoction combined with Tai Chi exercise,and those in the control group were given paroxetine hydrochloride;the course of treatment was 6 weeks for both groups.The two groups were observed in terms of the treatment outcome of depression and the scores of Self-Rating Depression Scale(SDS),Hamilton Depression Scale(HAMD),traditional Chinese medicine(TCM)syndrome,and Treatment Emergent Symptom Scale(TESS).Results:One patient in the treatment group and 2 patients in the control group were lost to follow-up.There was a significant difference in overall response rate of depression between the treatment group and the control group94.87%(37/39)vs 81.58%(31/38),P<0.05].Both groups had significant reductions in SDS,HAMD,and TCM syndrome scores after 2,4,and 6 weeks of treatment(P<0.01),and the treatment group had significantly lower SDS,HAMD,TESS,and TCM syndrome scores than the control group at each time point after treatment(P<0.05 or P<0.01).Conclusion:Modified Chaihu Longgu Muli decoction combined with Tai Chi exercise has a marked clinical effect in the treatment of depression with liver Qi stagnation and phlegm-heat,with little adverse effect,and therefore,it holds promise for clinical application.