152例艾滋病死亡病例的临床分析

目的总结分析新疆艾滋病(HIV/AIDS)病人死亡的主要原因。方法对新疆维吾尔自治区传染病医院2008年1月至2010年12月间,住院死亡的152例HIV/AIDS病人的病例资料进行回顾性总结,采用SPSS13.0统计软件进行分析。结果 152例HIV/AIDS病人中,男117例,女35例;平均死亡年龄37.17岁。吸毒感染者96例,性途径感染者49例,有偿献血感染者3例,不明原因感染者3例,母婴传播感染者1例。无业人员130例;中小学以下文化水平144例。122例查CD4细胞计数,其中CD4细胞>350个/μL 4例,≥200～350个/mL18例,<200个/μL 100例。抗病毒治疗(HAART)24例,最长服药时间为6个月。合并1种机会性感染者17例,合并2种机会性感染者54例,合并3种以上机会性感染者81例;主要合并结核病、肺炎、丙型肝炎(丙肝)、肺孢子菌肺炎(PCP)等。96例吸毒感染者中,11例曾行美沙酮替代治疗,79例在吸。结论 152例病人以吸毒人员为主,青壮年居多,HAART治疗覆盖面低,主要死于结核病、重症肺炎、丙肝肝硬化等。远离毒品,遏制艾滋,减少相关感染性疾病的传播,应加大宣传及干预力度。

Clinical analysis of 152 deceased HIV/AIDS cases

Objective To analyze the main causes of death of HIV/AIDS patients in Xinjiang.Method The HIV/AIDS cases who died in Xinjiang Infectious Disease Hospital from January 2008 to December 2010 were analyzed retrospectively,and software SPSS13.0 was used for statistical analysis.Result Among the 152 deceased patients,117 cases were males and 33 cases were females.Their average age of death was 37.17 years;96 cases had been infected with HIV by using drugs via needle sharing,49 cases-via sexual behaviors,3 via paid blood donation,3 had an unknown cause,and 1 via MCT.Of the deceased cases 130 were unemployed personnel;144 cases had educational background below primary and secondary schooling.Among the 122 cases who were tested for CD4 cell counts,4 had CD4 > 350 cells/μL,18 had CD4 between 350 and 200 cells/μL,100 had CD4 < 200 cells/μL.Twenty four cases received HAART and the longest time of treatment was 6 months;17 cases had 1 type of opportunistic infections,54 cases were complicated with two types of opportunistic infections and 81 cases were complicated with more than 3 types of opportunistic infections.They were mainly complicated with TB,pneumonia,hepatitis C,PCP,etc.Among the 96 drug addicts,11 cases received methadone replacement therapy,but 79 cases persisted in using drug.Conclusion The 152 deceased cases are mainly young people,most of whom are drug addicts.The coverage of HAART is lower.The main cause of death is TB,followed by serious pneumonia,hepatitis C,etc.To contain HIV/AIDS and to reduce related opportunistic infections,we should advocate to stay away from drugs,and strengthen public education and intervention efforts.