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| 克拉屈滨治疗经典型毛细胞白血病致间质性肺炎一例报道并文献复习 | |
| 引用本文： | 傅雷华,葛国兴,傅佳萍,张志坚,洪攀,封蔚莹.克拉屈滨治疗经典型毛细胞白血病致间质性肺炎一例报道并文献复习[J].中国全科医学,2020,23(8):989-992. |
| 作者姓名： | 傅雷华 葛国兴 傅佳萍 张志坚 洪攀 封蔚莹 |
| 作者单位： | 1.312000浙江省绍兴市人民医院 浙江大学绍兴医院血液科 2.312000浙江省绍兴市人民医院 浙江大学绍兴医院检验科 *通信作者：封蔚莹，主任医师；E-mail：f-wy@sohu.com |
| 基金项目： | 基金项目：浙江省医坛新秀培养计划（浙卫发〔2015〕70） |
| 摘 要： | 毛细胞白血病（HCL）是一种以脾大、全血细胞减少、骨髓组织增生等为临床表现的罕见慢性B淋巴细胞增殖性疾病。克拉屈滨作为其一线药物，对HCL的完全缓解率很高。本文报道了2017-09-04绍兴市人民医院收治的1例经典型HCL患者在克拉屈滨治疗期间，出现严重粒细胞缺乏伴高热，合并全身皮疹及间质性肺炎，经大剂量激素等治疗后好转的诊疗过程。并结合文献回顾了HCL的诊断及治疗方法，简述了克拉屈滨治疗HCL致间质性肺炎这一少见并发症的诊疗思路，以提高临床医师对该毒副作用的认识，为临床工作提供帮助。 |
| 关 键 词： | 毛细胞白血病 克拉屈滨 间质性肺炎 病例报告 |
Interstitial Pneumonia Caused by Cladribine in the Treatment of Classic Hairy Cell Leukemia：a Case Report and Literature Review |
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| FU Leihua,GE Guoxing,FU Jiaping,ZHANG Zhijian,HONG Pan,FENG Weiying.Interstitial Pneumonia Caused by Cladribine in the Treatment of Classic Hairy Cell Leukemia：a Case Report and Literature Review[J].Chinese General Practice,2020,23(8):989-992. | |
| Authors: | FU Leihua GE Guoxing FU Jiaping ZHANG Zhijian HONG Pan FENG Weiying |
| Institution: | 1.Department of Hematology，Shaoxing People's Hospital/Shaoxing Hospital，Zhejiang University School of Medicine，Shaoxing 312000，China 2.Clinical Laboratory，Shaoxing People's Hospital/Shaoxing Hospital，Zhejiang University School of Medicine，Shaoxing 312000，China *Corresponding author: FENG Weiying，Chief physician；E-mail: f-wy@sohu.com |
| Abstract: | Hairy cell leukemia（HCL） is a rare B-cell chronic lymphoproliferative disorder characterised by splenomegaly，pancytopenia and bone marrow involvement with fibrosis.Cladribine，as the first-line treatment for HCL，obtains a high complete remission rate.We reported herein a patient with classic HCL admitted by Shaoxing People's Hospital on September 4, 2017 who had received Cladribine treatment，underwent agranulocytosis with fever and complicated with systemic rash and interstitial pneumonia，and finally recovered after the administration of high dose of glucocorticoids.The diagnosis and treatment of HCL were reviewed with literatures retrospectively，and we summarized and analyzed the rare complication of interstitial pneumonia after Cladribine treatment，in order to improve clinicians' understanding of the adverse reaction and provide reference for clinical work. Hairy cell leukemia；Cladribine；Interstitial pneumonia；Case report |
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