免疫细胞在脓毒血症中的作用及机制研究进展

脓毒血症是由危及生命的感染所引起的宿主炎症反应，伴随着严重的器官功能衰竭和障碍。近年来，尽管医学和医疗技术都取得了巨大进步，脓毒血症的病死率仍高达30%~70%。脓毒血症本质上是机体对感染性因素的反应，初始免疫反应是一种过度炎症状态，随后迅速发展为免疫抑制状态。了解参与脓毒血症期间器官损伤发展中的宿主细胞介导的免疫反应是至关重要的。总结了各类免疫细胞在人和小鼠脓毒血症期间的作用变化及机制研究进展。

Advances in Research on the Role and Mechanism of Immune Cells in Sepsis

Sepsis is a host inflammatory response to a life-threatening infection with severe organ failure and dysfunction.In recent years,despite the tremendous progress in medicine and medical technology,the mortality rate of sepsis is still high(30%-70%).Sepsis is essentially the body's response to infectious factors,and the initial immune response is a state of excessive inflammation that rapidly progresses to an immunosuppressive state.It is important to understand the host cell-mediated immune response involved in the development of organ damage during sepsis.This article reviews the role and mechanisms of immune cells during sepsis in humans and mice.