| 微乳和基于微乳的经皮给药制剂的研究进展 |
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| 引用本文： | 刘筱雅,江昌照,高文彦,叶金翠. 微乳和基于微乳的经皮给药制剂的研究进展[J]. 中国医药工业杂志, 2020, 0(4): 442-449 |
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| 作者姓名： | 刘筱雅 江昌照 高文彦 叶金翠 |
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| 作者单位： | 浙江省医学科学院药物研究所 |
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| 基金项目： | 浙江省科技厅项目(2017C33147);浙江省神经精神疾病药物研究重点实验室资助项目(2019E10021)。 |
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| 摘 要： | 近年来,微乳作为一种具有粒径小、渗透性强、溶解度大、易于制备的新型递药载体,在药物制剂的开发过程中得到广泛研究。本文总结了近年来国内外微乳和基于微乳的经皮给药制剂在不同种类药物中应用的相关文献,介绍了微乳的组成、形成机制、优缺点及在各治疗领域的研究实例。微乳具有促进药物透皮吸收、提高稳定性、延长作用时间和降低皮肤刺激性的优势,因此在经皮给药制剂领域具有广阔的应用前景。
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| 关 键 词： | 微乳 经皮给药制剂 研究进展 |
Progress of Microemulsion and Microemulsion-based Transdermal Preparations |
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| LIU Xiaoya,JIANG Changzhao,GAO Wenyan,YE Jincui. Progress of Microemulsion and Microemulsion-based Transdermal Preparations[J]. , 2020, 0(4): 442-449 |
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| Authors: | LIU Xiaoya JIANG Changzhao GAO Wenyan YE Jincui |
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| Affiliation: | (Key Lab.of Neuropsychiatric Drug Research of Zhejiang Province,Institute of Materia Medica,Zhejiang Academy of Medical Sciences,Hangzhou 310013) |
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| Abstract: | In recent years,as a new drug delivery system with advantages of small particle size,enhanced permeation,high solubility and easy to prepare,microemulsion has been widely studied in the development of pharmaceutical preparations.This paper summarizes the related references of microemulsion and microemulsion-based transdermal preparations applied to different types of drugs at home and abroad in recent years,and introduces the formulation composition,formation mechanism,advantages and disadvantages of microemulsion and research cases in various therapeutic fields.Microemulsion has broad application prospects in the field of transdermal preparations because of its advantages of promoting transdermal penetration,improving stability,prolonging therapeutic duration and reducing skin irritation. |
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| Keywords: | microemulsion transdermal preparation research progress |
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