氟康唑与达克宁栓联合治疗复发性念珠菌性阴道炎的临床疗效分析

目的分析氟康唑联合硝酸咪康唑栓(商品名:达克宁栓)治疗复发性念珠菌性阴道炎的临床疗效。方法400例复发性念珠菌性阴道炎患者,按照随机数字法分为联合组和对照组,各200例。联合组使用氟康唑+达克宁栓治疗,对照组单用达克宁栓治疗。比较两组治疗效果、临床症状消失时间、疾病复发率、治疗后的炎性因子水平、不良反应发生率、治疗满意度。结果联合组治疗总有效率96.0%高于对照组的78.0%,差异有统计学意义(P<0.05)。联合组白带异常、外阴瘙痒排尿困难的消失时间分别为(12.5±2.6)、(6.1±1.4)、(8.1±2.2)d,均短于对照组的(20.1±2.9)、(7.9±1.9)、(12.1±3.0)d,差异有统计学意义(P<0.05)。联合组治疗后90 d和180 d的疾病复发率分别为0、1.0%,均低于对照组的4.5%、9.0%,差异有统计学意义(P<0.05)。联合组患者C反应蛋白、白细胞介素-6、肿瘤坏死因子-ɑ水平分别为(3.20±0.81)ng/L、(2.45±0.72)pg/L、(41.23±9.24)pg/L,低于对照组的(5.88±1.95)ng/L、(4.19±1.16)pg/L、(80.66±10.65)pg/L,差异有统计学意义(P<0.05)。联合组不良反应发生率为1.5%,低于对照组的9.0%,差异有统计学意义(P<0.05)。联合组患者治疗总满意度98.0%高于对照组的87.5%,差异有统计学意义(P<0.05)。结论对复发性念珠菌性阴道炎患者应用氟康唑+达克宁栓治疗可取得显著疗效,能快速缓解其临床症状,且治疗后复发率低,用药安全性有保障,此治疗方法深受患者好评,适宜在临床中推广应用。

Analysis of clinical efficacy of fluconazole combined with Dakening suppository in the treatment of recurrent candidal vaginitis

Objective To analyze the clinical efficacy of fluconazole combined with miconazole nitrate suppositories(trade name:Dakening suppository)in the treatment of recurrent candidal vaginitis.Methods A total of 400 patients with recurrent candidal vaginitis were divided into combination group and control group by random number table method,with 200 cases in each group.The combination group was treated by fluconazole combined with Dakening suppository,and the control group was treated by Dakening suppository.The therapeutic effect,disappearance time of clinical symptoms,disease recurrence rate,levels of inflammatory factors,occurrence of adverse reactions and satisfaction of treatment after treatment were compared between the two groups.Results The total effective rate of treatment 96.0%of the combination group was higher than that of the control group 78.0%,and the difference was statistically significant(P<0.05).The disappearance time of leucorrhea abnormalities,genital itching,difficulty urinating of the combination group were(12.5±2.6),(6.1±1.4)and(8.1±2.2)d respectively,which were shorter than those of the control group(20.1±2.9),(7.9±1.9)and(12.1±3.0)d,and the difference was statistically significant(P<0.05).The disease recurrence rate 90 and 180 d after treatment of the combination group were 0 and 1.0%respectively,which were lower than those of the control group 4.5%and 9.0%,and the difference was statistically significant(P<0.05).The levels of C-reactive protein,interleukin-6 and tumor necrosis factor-ɑof the combination group were(3.20±0.81)ng/L,(2.45±0.72)pg/L and(41.23±9.24)pg/L respectively,which were lower than those of the control group(5.88±1.95)ng/L,(4.19±1.16)pg/L and(80.66±10.65)pg/L,and the difference was statistically significant(P<0.05).The incidence of adverse reactions of the combination group was 1.5%,which was lower than that of the control group 9.0%,and the difference was statistically significant(P<0.05).The total satisfaction of treatment 98.0%of the combination group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Fluconazole combined with Dakening suppository shows remarkable efficacy for patients with recurrent candidal vaginitis,which can quickly relieve its clinical symptoms.The recurrence rate after treatment is low,and the safety of medication is guaranteed.This treatment method is well received by patients,and is suitable for clinical promotion and application.