Anti-angiogenic activity of a homoisoflavanone from Cremastra appendiculata |
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| Authors: | Shim Joong Sup Kim Jin Hee Lee Jiyong Kim Si Na Kwon Ho Jeong |
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| Affiliation: | Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, Kwangjin-gu, Seoul, Korea. |
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| Abstract: | ![]()
A homoisoflavanone, 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one ( 1), was isolated from the bulb of Cremastra appendiculata (D. Don) Makino (Orchidaceae) as a potent inhibitor of angiogenesis. It inhibited basic fibroblast growth factor (bFGF)-induced in vitro angiogenesis and in vivo angiogenesis of the chorioallantoic membrane (CAM) of chick embryo without showing any toxicity. |
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