| 阿尔茨海默病新药开发现状 |
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| 引用本文： | 李嘉和,王颖实,尤海明.阿尔茨海默病新药开发现状[J].中国新药杂志,2003,12(10):794-803. |
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| 作者姓名： | 李嘉和 王颖实 尤海明 |
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| 作者单位： | 1. 深圳市天和医药科技开发有限公司,深圳,518057
2. 深圳市天明医药科技开发有限公司,深圳,518057 |
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| 摘 要： | 阿尔茨海默病(AD)的病因尚不十分清楚。目前，以β淀粉样蛋白为中心的生理病理学说被广泛接受。简要描叙该病理过程，从抑制β-淀粉样蛋白新药科研入手，全面综述了近年来西方开发抗AD新药研究的进展.
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| 关 键 词： | AD β-淀粉样蛋白 β-分泌酶抑制剂 新药开发 |
| 文章编号： | 1003-3734(2003)10-0794-10 |
Development of new agents for treatment of Alzehemer's disease |
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| Li Jia-he,Wang Ying-shi,YOU Hai-ming.Development of new agents for treatment of Alzehemer''s disease[J].Chinese Journal of New Drugs,2003,12(10):794-803. |
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| Authors: | Li Jia-he Wang Ying-shi YOU Hai-ming |
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| Abstract: | The causes of Alzeheimer's disease have not yet been fully elucidated. The beta-amyloid plaques formation hypothesis was broadly accepted. The progress in new drug development based on this hypothesis in resent years was reviewed in this paper. |
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| Keywords: | Alzheimer's disease beta-amyloid beta-secrease inhibitors drug discovery |
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