唾液、牙斑与胃黏膜幽门螺杆菌感染关系的研究

背景幽门螺杆菌(H.pyloori)在人群中感染率高,但其传播途径仍不清楚.目前有关口腔中H.pylori感染与胃黏膜H.plori感染关系的研究不多.目的了解口腔中的H.pylori感染状况及其与胃黏膜H.pylori感染的关系.方法应用聚合酶链反应(PCR)技术同时检测60例非萎缩性胃炎患者唾液、牙斑和胃黏膜中的H.pylori.结果47例胃黏膜H.pylori阳性的胃炎患者中有31例(66.0%)唾液中检出H.pylori,17例(36.2%)牙斑中检出H.pylori;而13例胃黏膜H.pylori阴性的胃炎患者中仍有1例(7.7%)唾液中检出H.pylori,2例(15.4%)牙斑中检出H.pylori.胃黏膜H.pylori阳性与阴性胃炎患者唾液和牙斑中的H.pylori检出率有显著差异(P＜0.01).结论口腔中的H.pylori与胃黏膜中的H.pylori之间可能存在一定的病因学联系.

Relevance of Helicobacter pylori Infection in Saliva, Dental Plaque and Gastric Mucosa

Helicobacter pylori (H. pylori) infection is common worldwide, but the route of transmission remains uncertain. Now there are only few studies on the relevance of oral H. pylori and gastric H. pylori infection. Aims: To investigate the status of oral H. pylori infection and its relevance to gastric H. pylori infection. Methods: H. pylori was detected in saliva, dental plaque and gastric mucosa of 60 patients with non atrophic gastritis by polymerase chain reaction (PCR). Results: In 47 patients with H. pylori positive gastritis, H. pylori was found in saliva and dental plaque in 31 (66.0%) and 17 (36.2%) patients, respectively; while in 13 patients with H. pylori negative gastritis, H. pylori was found in saliva and dental plaque in only 1(7.7%) and 2(15.4%) patients, respectively. There was a significant difference in the detection rates of H. pylori in saliva and dental plaque between H. pylori positive and negative gastritis (P<0.01). Conclusions: There may be some etiological relationship between oral H. pylori infection and gastric H. pylori infection.