诱导型一氧化氮合酶和内皮型一氧化氮合酶在胃癌中的表达关系及临床意义

目的 检测诱导型一氧化氮合酶(iNOS)、内皮型一氧化氮合酶(eNOS)在小鼠正常胃组织及原位移植人胃癌组织SGC-7901中的表达情况,探讨严重联合免疫缺陷(SCID)小鼠胃癌不同阶段时iNOS和eNOS含量变化的相关性研究及临床意义.方法 采用苏木精-伊红染色法进行检测.结果 可见eNOS和iNOS在10只正常胃组...

The expression relationship and clinical significance of induction nitric oxid esynthase and endothelial nitric oxide synthase in stomach cancer

Objective To detect the expression of inducible nitric oxidesynthase(iNOS),endothelial nitric oxide synthasee(eNOS),gastric cancer tissue in normal gastric tissue and in-place transplant patients,SGC-7901,and to investigate the correlation between changes in iNOS and eNOS content at different stages of stomach cancer in SCID mice,and clinical significance.Methods The detection was carried out by sumu-I-red dyeing method.Results It can be seen that the correlation between eNOS and iNOS was weak in 10 cases of normal stomach tissue,and in 30 cases of gastric cancer tissue,there was a significant difference between 25 cases of iNOS expression significantly higher than normal stomach tissue(83%vs 38%,P<0.05),and iNOS was associated with the development of stomach cancer.In 17 of the 30 gastric cancer tissues,eNOS expression was slightly higher than that of normal gastric cancer tissue(57%vs 20%,P<0.05).iNOS is associated with the expression of eNOS in gastric cancer tissue(P<0.01).Conclusion There may be interactions between eNOS and iNOS that are involved in metastasis and immersion for the development of stomach cancer.