Torquetenovirus viremia kinetics after autologous stem cell transplantation are predictable and may serve as a surrogate marker of functional immune reconstitution |
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| Authors: | Daniele Focosi Fabrizio Maggi Melania Albani Lisa Macera Valentina Ricci Silvia Gragnani Serena Di Beo Massimo Ghimenti Guido Antonelli Mauro Bendinelli Mauro Pistello Luca Ceccherini-Nelli Mario Petrini |
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| Affiliation: | 1. Division of Hematology, Azienda Ospedaliera Universitaria Pisana “Santa Chiara”, Pisa, Italy;2. Virology Section and Retrovirus Centre, Department of Experimental Pathology, University of Pisa, Via San Zeno, 35-37, 56127 Pisa, Italy;3. Division of Laboratory Analysis, University of Pisa, Italy;4. Virology Section, Department of Experimental Medicine, Sapienza University, Rome, Italy;1. Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”, Trieste, Italy;2. Department of Medical Science, University of Trieste, Trieste, Italy;1. Young Researchers and Elite club, Central Tehran Branch, Islamic Azad University, Tehran, Iran;2. Department of Chemistry, College of Science, Central Tehran Branch, Islamic Azad University, Tehran, Iran;1. Microbiology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain;2. Hematology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain;3. Department of Medicine, School of Medicine, University of Valencia, Valencia, Spain;4. Virology Unit, Pisa University Hospital, Pisa, Italy;5. North-Western Tuscany Blood Bank, Pisa University Hospital, Pisa, Italy;6. Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain;1. Service d''Hématologie Greffe, AP-HP Hôpital Saint Louis, Paris, France;2. AP-HP Hôpital Saint Louis, DBIM, Paris, France;3. Immunologie, AP-HP Hôpital Saint Louis, Paris, France;4. Inserm U 940, Hôpital Saint Louis, Paris, France;5. Service des Maladies Infectieuses et Tropicales, AP-HP Hôpital Saint Louis, Paris, France;6. Université Paris Diderot, Sorbonne Paris Cité, France;1. UMR INSERM 1092, Université de Limoges, National Reference Center For Herpesviruses, Bacteriology-Virology-Hygiene Department, CHU Limoges, 2 ave ML King, 87000, Limoges, France;2. bioMérieux, 138 rue Louis Pasteur, Parc technologique Delta Sud, 09340, Verniolle, France;3. Nephrology and Transplantation Department, CHU Limoges, 2 ave ML King, 87000, Limoges, France;4. bioMérieux, Centre Christophe Mérieux, 5 rue des Berges, 38024, Grenoble cedex 01, Grenoble, France;5. Intensive Care Unit Department, CHU Limoges, 2 ave ML King, 87000, Limoges, France;1. Hematology Division, Pisa University Hospital, Pisa, Italy;2. Dudakov Lab, Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;3. Biostatistical Consulting, Pisa University Hospital, University of Pisa, Pisa, Italy;4. Virology Unit and Retrovirus Centre, Pisa University Hospital, Pisa, Italy |
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| Abstract: | ![]()
BackgroundIt is common experience that retreating patients too early after a course of intensive chemotherapy predisposes to opportunistic infections despite apparently normal lymphocyte levels.ObjectivesThe extent of replication of persistent viruses that cause no obvious disease (and hence need no treatment) might better define when a patient has recovered from functional immune deficiency.Study designWe used real-time polymerase chain reaction to monitor the kinetics of plasma torquetenovirus (TTV) viremia in hematological patients undergoing autologous hematopoietic stem cell transplantation as support to high-dose chemotherapy (HSCT).ResultsIndependently from underlying hematological disease and therapeutic regimen, TTV viremia increased post-HSCT, and this increase paralleled the increase of circulating CD8+CD57+ T lymphocytes, known to represent an indirect marker of functional immune deficiency. Subsequently, within a matter of months, TTV levels returned to baseline values, at a pace that appeared to be constant over time.ConclusionMonitoring of TTV viremia represents a unique opportunity to follow functional immune reconstitution in immunosuppressed patients. Also, the size of the TTV viremia increases resulting from immunosuppressive treatments might be of guidance in determining the appropriate time interval before delivery of a next course of therapy. |
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