脱细胞真皮基质与自体刃厚皮片复合移植的临床及组织学观察

目的 观察异体脱细胞真皮基质与自体刃厚皮片复合移植修复创面的中、长期临床效果,并做组织学观察.方法 选取23例接受异体脱细胞真皮基质加自体刃厚皮片复合移植的患者,于术后3、6、12、18个月进行临床随访,并作组织学观察.结果 移植后3、6、12、18个月,复合皮表面平滑,无明显瘢痕增生及色素沉着现象,柔软有弹性,关节部位活动自如.组织学观察接近正常皮肤形态.结论 异体脱细胞真皮基质与自体刃厚皮片复合移植后愈合创面表面光滑,平整柔软,无明显挛缩,关节活动自如,未见明显排汗现象,可作为修复创面的良好选择.

Histologic analysis and long-term effect of acellular dermal matrix combined with autologous thin split-thickness skin graft

Objective To evaluate the long-term therapeutic effect and histologic result of ADM combined with autologous thin split-thickness skin graft. Methods 23 patients were treated with acellalar dermal matrix (ADM) combined with autoiogous thin split-thickness skin graft. The patients were followed up at 3, 6, 12, and 18 months after operation. The histological analysis was also performed. Results 3,6, 12, 18 months after operation, the composite skin grafts became smooth with no hypertrophic scar and hyperpigmentation. It was soft and elastic. The joints could move randomly. The histologic study showed the composite skin graft had a similar appearance as the normal skin. Conclusion As for the treatment of wound, the composite skin graft with ADM is smooth and soft with good elasticity after transplantation, but it has no perspiration.