| 实验性糖尿病大鼠主动脉超微结构研究 |
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| 引用本文： | 赵西原,吴家祥,张凤兰,蔡世喜,李艳丽. 实验性糖尿病大鼠主动脉超微结构研究[J]. 吉林大学学报(医学版), 1989, 0(5) |
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| 作者姓名： | 赵西原 吴家祥 张凤兰 蔡世喜 李艳丽 |
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| 作者单位： | 白求恩医科大学病理解剖教研室(赵西原，吴家祥，张凤兰)，白求恩医科大学一院中心实验室(蔡世喜)，白求恩医科大学一院化验科(李艳丽) |
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| 摘 要： | 本实验对STZ—DM大鼠的主动脉进行了超微结构观察。结果显示,DM大鼠血浆胰岛素水平明显降低,血糖含量明显增高、血浆TC、LDL—C、LDL—C/HDL—C、TC/HDL-C值明显增高,HDL—C明显降低,与对照组比较均有显著差异(P<0.01)。电镜下,DM大鼠主动脉有早期AS病变。结果表明,急性实验性DM,由胰岛素绝对缺乏所致的高血糖、高TC、高LDL—C以及低HDL—C血症,可能与主动脉早期AS病变的形成密切相关。
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| 关 键 词： | 糖尿病(DM) 主动脉 高密度脂蛋白(HDL) 脲菌链霉素(STZ) |
Ultrastructural study on the aortic wall in rats with STZ-i nduced diabetes |
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| Zhao Xiyuan,et al. Ultrastructural study on the aortic wall in rats with STZ-i nduced diabetes[J]. Journal of Jilin University: Med Ed, 1989, 0(5) |
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| Authors: | Zhao Xiyuan et al |
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| Affiliation: | Department of Pathology |
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| Abstract: | Ultrastructue of the aortic wall in rats with diabetes induced by STZ is studied.The radioimmunologic and biochemical data obtained show a significant decrease in plasma insulin level and a significant increase in blood glucose content in diabetic as compared with the normal rats (P<0.01).TC, LDL-C, LDL-C/HDL-C and TC/HDL-C are increased, but HDL-C is significantly de-creased in diabetic rats.Under SEM and TEM, early atherosclerotic ohanges are found in the aortic wall of diabetic rats.The results show that,in acute exper-imental diabetes, hyperglycemia, hypercbolesterolemia, hyperlipemia of LDL-C and hypolipemia of HDL-C resulted from absolute hypoinsulinism may be close-ly related to the formation of early aortic atherosclerotic changes. |
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| Keywords: | Diabetes mellitas Aorta Highrdensity lipoprotein Streptozocin (STZ) |
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