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| 自发性糖尿病大鼠生长发育与繁殖研究 | |
| 引用本文： | 孙鲁洪,戴荣,张晓峰,蔡松年. 自发性糖尿病大鼠生长发育与繁殖研究[J]. 复旦学报(医学版), 1989, 0(1) |
| 作者姓名： | 孙鲁洪 戴荣 张晓峰 蔡松年 |
| 作者单位： | 上海医科大学实验动物部(孙鲁洪，戴荣)，上海医科大学眼耳鼻喉科医院(张晓峰)，上海医科大学眼耳鼻喉科医院(蔡松年) |
| 摘 要： | 本试验应用从加拿大引种自发性糖尿病大鼠(简称BB Wistar大鼠)进行一年半的饲养繁殖试验。通过对该动物的生长发育、代谢观察及脏器重量等项指标的检测以及对影响其子代发病率的因素进行了讨论。结果证明:自发性糖尿病大鼠后代发病率较高(10％～39％),不同家系内和亲代不同交配方式影响子代发病率。此外,发病鼠的生长发育、机体代谢与人类青年型糖尿病十分相似。BB Wistar大鼠可作为一种自发性动物模型用于人类青年型糖尿病及其并发症的研究。 |
| 关 键 词： | 自发性糖尿病BBWistar鼠 动物模型 饲养繁殖 |
STUDIES ON GROWTH AND REPRODUCTION IN BB WISTAR RATS WITH SPONTANEOUS DIABETES |
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| Sun Luhong,Dai Eong,Zhang Xiaofeng,Cai Songnian. STUDIES ON GROWTH AND REPRODUCTION IN BB WISTAR RATS WITH SPONTANEOUS DIABETES[J]. Fudan University Journal of Medical Sciences, 1989, 0(1) | |
| Authors: | Sun Luhong Dai Eong Zhang Xiaofeng Cai Songnian |
| Abstract: | BB Wistar rats obtained from Health and Welfare, Canada, were observed on feeding, growth and development, metabolism, organ weight changes and reproduction. Assorted genetic mating resulted in different rates of occurrence of overt diabetes in the progeny. Body growth and metabolism in the diabetic rats resemble human juvenile diabetes greatly. Thus, BB "Wistar rats might be valuable as an animal model in the study of human juvenile diabetes and its complication. |
| Keywords: | spontaneous diabetic BB Wistar rat animal model feed and reproduction |
| 本文献已被 CNKI 等数据库收录！ | |