应用文献计量学与可视化分析探讨骨与关节结核的全球研究现状及发展趋势

文题释义：文献计量学：运用数学和统计学方法对书面文件或发表文献进行研究的一种方法，可表现出一门学科或专业在发展过程中书面沟通材料的变化与特点，可是对书面交流材料的各个方面(题目、作者、发表年限和主要内容等)进行量性分析。 可视化：是利用计算机图形学和图像处理技术将数据转换成图形或图像在屏幕上显示出来，再进行交互处理的理论、方法和技术。 背景：探讨近年来骨与关节结核的研究现状及发展趋势，有利于更加深入地认识骨与关节结核，把握好研究方向，可能会给骨与关节结核的早期诊断、及时治疗提供线索。 目的：分析骨与关节结核的全球研究现状及发展趋势。 方法：以骨与关节结核为主题，通过科学引文索引扩展数据库Wed of Science检索1994至2018年关于骨与关节结核的文献出版物，并使用文献计量学的方法对进行数据统计及研究。使用Vos viewer软件进行共现分析及合著分析等可视化转化，分析近年骨与关节结核的研究现状及热点转变。 结果与结论：①引文研究共纳入2 761篇文献，全球文献发表呈逐年上升趋势，其中美国发表的文献数量、被引用次数及H指数均最高，中国在全球文献发表量排行第3，文献被引用总次数排行第12，H指数排在第13；②《PloS One》《Journal of  immunology》和《Infection and immunity》杂志的出版物发表量分列前三，中南大学、开普敦大学和伦敦大学学院是文献发表物数量前三的机构；③该领域的研究目前可分为6大类：早期诊断与治疗、脊柱结核的治疗与并发症、骨与关节结核的发病特点、分子生物学检测、细胞学和免疫学研究，GeneXpert MTB/RIF在骨与关节结核的应用可能是当前的研究热点；④骨与关节结核的研究在不断深化，对应的文献出版物数量将不断增加，其中美国是这一领域的较大贡献者；目前的研究主要集中于骨与关节结核的诊断与治疗，GeneXpert MTB/RIF与骨关节结核的关系可能是当前的研究热点。 ORCID: 0000-0001-5146-4727(何晓铭) 中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Trends in global research on bone and joint tuberculosis: bibliometrics and visual analysis

BACKGROUND:Herein,we investigate the research status and development trend of bone and joint tuberculosis in recent years,and deepen the understanding of bone and joint tuberculosis,which may provide clues for early diagnosis and timely treatment of bone and joint tuberculosis.OBJECTIVE:To analyze the global research status and development trend of bone and joint tuberculosis.METHODS:Web of science was searched for publications addressing bone and joint tuberculosis from 1994 to 2018.Retrieval data were statistically analyzed by bibliometrics method.The Vos viewer software was used for the visualization transformation of co-occurrence analysis and co-production analysis.The current situation and trend of bone and joint tuberculosis in recent years were then analyzed.RESULTS AND CONCLUSION:A total of 2761 studies were included in the study,indicating a global increase in the number of publications year by year.The United States has the largest number of publications,highest times cited and H index.China ranks 3rd in global literature publication,12th in total citations and 13th in the H index.Publications in PloS One,Journal of Immunology and Infection and Immunity rank top three.The University of Central South,the University of Cape Town and University College London are the top three institutions in terms of the number of publications.Studies on bone and joint tuberculosis could fall into six categories:early diagnosis and treatment of tuberculosis,treatment and complications of spinal tuberculosis,characteristics of pathogenesis in bone and joint tuberculosis,molecular detection of bone and joint tuberculosis,cytology of bone and joint tuberculosis,and relationship between osteoarthritis tuberculosis and immunology.GeneXpert MTB/RIF may become the hot research topic.The trend of global research on bone and joint tuberculosis indicates that literature regarding bone and joint tuberculosis is increasing,and the United States is the largest contributor.Current studies have focused on the diagnosis and treatment of bone and joint tuberculosis,and the relationship between GeneXpert MTB/RIF and bone and joint tuberculosis may become the hot research topic.