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| 腭部中线恶性网织细胞增生症临床病理及免疫组化研究 | |
| 引用本文： | 陈列,刘卫平,刘一,李俸媛,周志瑜. 腭部中线恶性网织细胞增生症临床病理及免疫组化研究[J]. 四川大学学报(医学版), 1994, 0(3) |
| 作者姓名： | 陈列 刘卫平 刘一 李俸媛 周志瑜 |
| 作者单位： | 1 Department of Oral pathology; 2 Department of Pathology，TheFirst Affiliate Hospital |
| 摘 要： | 总结分析了１４例腭部中线恶性网织细胞增生症（中线恶网）的临床病理及免疫组化特点。１４例（男１０例，女４例）患者发病高峰年龄在２１～３０岁年龄段，临床表现为腰部肿胀、渍疡或穿孔，可合并鼻腔、上颌窦及皮肤损害。光镜下以凝固性坏死、非特异性炎症背景上散布异型淋巴样细胞为特征，其中２例标本在部分高倍视野中出现异型淋巴样细胞似恶性淋巴瘤的增生改变。免疫组化结果显示：１４例中１０例之异型淋巴样细胞来源于Ｔ淋巴细胞，另４例可能由于抗体丢失等原因无法确立来源。作者认为中线恶网本质为恶性淋巴瘤，且大部分为Ｔ细胞源性。但其在临床及组织学上与恶性淋巴瘤有一定差别，应作为一个独立概念存在。此外，中线恶网在形态学上可以向恶性淋巴瘤转化。 |
| 关 键 词： | 中线恶网，临床病理，免疫组织化学，异型淋巴样细胞，恶性淋巴瘤 |
Clinicopathologic and Immunohistochemical Studies of Midline Malignant Reticulosis in Palate |
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| Abstract: | Fourteen patients(10 males and 4 fe-males)with midline malignant reticulosis(MMR)inpalate were studied.The symptoms were most com-monly swelling and ulceration. In some cases, the le-sion involved nasal, maxillary sinus and facial skin,but no regional lymph nodes were involved.A necro-tizing infiltration of atypical lymphoid cells(ALCs)mixed with inflammatory cells was confirmed as thehistopathologic feature of MMR. In 2 of 14 cases,ALCs formed a continuous sheet in several high-powerfields with a few inflammatory cells. This overlappingfeature may be a transitional form between MMR andmalignant lymphoma. Immunohistochemical stainingresults indicated that in 10 of 14 cases, ALCs wereCD3 positive; in 7 of 14 cases, ALCs were UCHL1ppositive; and in all 14 cases, ALCs were L26 nega-tive. We deem MMR a T-cell lymphoma in substance,but it should be treated as a histopathologic entity dis-tinct from malignant lymphoma. |
| Keywords: | Midline malignant reticulosis Clinicopathogy Immunohistochemisry Atypical lymphoid cell Malignant lymphoma |
| 本文献已被 CNKI 等数据库收录！ | |