急性缺血性卒中血清高敏C-反应蛋白水平变化与病情及预后的关系

目的探讨急性缺血性卒中(AIS)血清高敏C-反应蛋白(hsCRP)水平变化与病情及预后的关系。方法 124例AIS患者于入院后第2天(发病后72h内)、第7天和第14天分别抽血检测,采用免疫比浊法,用全自动生化分析仪测定血清hsCRP浓度。结果完全性AIS组与进展性AIS组在发病后72h内及1周血清hsCRP水平,两两比较差异有统计学意义(P0.05)。预后不良组发病后不同时期血清hsCRP浓度均明显高于良好组,比较差异有统计学意义(P0.05)。血清hsCRP水平与患者入院时及治疗3个月后的BI评分呈显著负相关(r=-0.45、0.40,P均0.01)。结论 AIS患者血清hs-CRP水平增高,与疾病严重程度呈正相关,并随发病后的时间而变化。因此,炎性反应可能在AIS的病理机制起重要作用,检测hs-CRP水平有望成为脑梗死评估病情及预后的指标之一。

Relationship between Serum High-sensitivity C-reactive Protein Level and Condition and Prognosis of Acute Ischemic Stroke

Objective To investigate the relationship between the change in the serum high-sensitivity C-reactive protein （hs-CRP） level and the condition and prognosis of acute ischemic stroke （AIS）. Methods The blood test was carried out in 124 cases of AIS at 2 （within 72 hours）, 7 and 14 days after admission to hospital and the serum hs-CRP level was measured with an automatic biochemical analyzer by immunoturbidimetry. Results There was a significant difference （P〈0.05） in the serum hs-CRP level between the complete AIS group and the progressive AIS group within 72 hours and one week after AIS onset. The serum hs-CRP level of the poor prognosis group was significantly higher than that of the better prognosis group at the different time points, with a significant difference （P〈0.05） The serum hs-CRP level showed a significantly negative correlation （r=-0.45,0.40,both P〈0.01） with the BI score at admission and after 3- month treatment. Conclusion The serum hs-CRP level increases in AIS and has a positive correlation with the disease severity, showing a time-dependent pattern. Therefore, the inflammatory response may play an important role in the pathological mechanism of AIS, and the detection of the hs-CRP level will become one of the indicators in assessing the condition and prognosis of cerebral infarction.