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| 15-PGDH在大肠腺癌中的表达 | |
| 引用本文： | 曹仕琼,魏文杰,熊枝繁. 15-PGDH在大肠腺癌中的表达[J]. 临床消化病杂志, 2010, 22(1). DOI: 10.3870/lcxh.j.issn.1005-541X.2010.01.009 |
| 作者姓名： | 曹仕琼 魏文杰 熊枝繁 |
| 作者单位： | 华中科技大学同济医学院附属梨园医院消化内科,武汉,430077 |
| 摘 要： | 目的研究NAD+依赖性15-羟基前列腺素脱氢酶(15-PGDH)在大肠腺癌组织、大肠腺瘤组织及正常大肠组织中的表达,探讨15-PGDH在大肠腺癌组织中的表达情况及其与大肠腺癌临床病理因素的关系。方法应用免疫组织化学(SABC)法检测40例大肠腺癌组织、20例大肠腺瘤组织和20例正常大肠组织中15-PGDH的表达情况。结果15-PGDH在大肠腺癌(15%)和腺瘤组织(20%)中的阳性表达率显著低于在正常大肠组织(100%)中的阳性表达率(P0.01),而15-PGDH在大肠腺癌和腺瘤中的表达无统计学差异(P0.05)。15-PGDH蛋白表达情况与大肠腺癌患者的性别、年龄、分化程度及Dukes分期和有无淋巴结转移等临床病理参数均无关系(P0.05)。结论大肠腺癌组织中15-PGDH表达减少或缺失,且其表达与大肠腺癌的分期分化等病理参数并无关系。15-PGDH的表达缺失或减少可能发生在大肠腺癌发生发展的早期,是大肠腺癌发生的抑制物。 |
| 关 键 词： | NAD+依赖性15-羟基前列腺素脱氢酶 大肠腺癌 大肠腺瘤 |
The Expression of 15-PGDH in Colorectal Adenocarcinoma |
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| CAO Shi-qiong,WEI Wen-Jie,XIONG Zhi-fan. The Expression of 15-PGDH in Colorectal Adenocarcinoma[J]. Chinese Journal of Clinical Gastroenterology, 2010, 22(1). DOI: 10.3870/lcxh.j.issn.1005-541X.2010.01.009 | |
| Authors: | CAO Shi-qiong WEI Wen-Jie XIONG Zhi-fan |
| Affiliation: | CAO Shi-qiong,WEI Wen-Jie,XIONG Zhi-fan Department of Gastroenterology,Liyuan Hospital,Tongji Medical College of Huazhong University of Science , Technology,Wuhan,430077,China |
| Abstract: | Objective To investigate the expression of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase(15-PGDH)in colorecta adenocarcinoma,colorectal adenoma and normal coloretal mucosa specimens and its possible implications.Methods Immumohistochemical staining was used to detect the expression of 15-PGDH protein in colorectal adenocarcinoma(n=40),colorectal adenoma(n=20) and normal colorectal mucosa(n=20).Results The expression rate of 15-PGDH in colorectal adenocarcinoma(15%) and colorectal adenoma(20%) was sig... |
| Keywords: | NAD+-dependent 15-hydroxyprostaglandin dehydrogenase Colorectal adenocarcinoma Colorectal adenoma |
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