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Phenylpropionic Acid-Based Cyclic Prodrugs of Opioid Peptides that Exhibit Metabolic Stability to Peptidases and Excellent Cellular Permeation |
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| Authors: | Gudmundsson Olafur S. Nimkar Kalpana Gangwar Sanjeev Siahaan Teruna Borchardt Ronald T. |
| Affiliation: | (1) Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas, 66047;(2) Present address: Bristol-Myers Squibb, Exploratory Biopharmaceutics and Drug Delivery, Pharmaceutical Reseach Institute, One Squibb Drive, P.O. Box 191, New Brunswick, New Jersey, 08903-0191;(3) Present address: Coulter Pharm., Inc., 550 California Avenue, Ste. 200, Palo Alto, California, 94306 |
| Abstract: | |
| Keywords: | esterase-sensitive prodrugs peptide delivery opioid peptides Caco-2 cells membrane permeability chemical and enzymatic stability |
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