疏血通对急性冠脉综合征介入治疗术后的影响 |
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引用本文: | 宋景春,黄国明,丁仲如,郑春辉,揭继焘. 疏血通对急性冠脉综合征介入治疗术后的影响[J]. 陕西医学杂志, 2009, 38(4): 439-441 |
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作者姓名: | 宋景春 黄国明 丁仲如 郑春辉 揭继焘 |
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作者单位: | 江西南昌解放军第94医院心内科,南昌,330002 |
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摘 要: | 目的:观察疏血通对急性冠脉综合征(ACS)患者介入治疗(PCI)前后内皮功能、纤溶活性的影响,并探讨疏血通治疗与PCI治疗后早期心脏相关并发症的关系。方法:选择2006年3月至2008年1月在我院心导管室行PCI治疗的84例患者为研究对象,PCI术后随机分为两组,对照组给予常规治疗,疏血通组在常规治疗基础上于术后第1天加用疏血通静滴1周。所有患者于PCI前1天、术后1周分别测定血浆纤溶酶原激活物(t-PA)、抑制物(PAI-I)、假性血友病因子(vWF)的影响,并观察心脏事件发生率。结果:疏血通组患者血浆vWF和PAI-I水平降低,而t-PA活性增加,与对照组比较有显著差异(P<0.05),并且疏血通组与对照组相比心脏事件发生率有降低的趋势(P<0.05)。结论:ACS患者PCI术后应用疏血通可以改善内皮功能和纤溶活性,减少心脏事件的发生。
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关 键 词: | 冠状动脉疾病/治疗 @冠脉介入术 @疏血通 纤溶酶原激活剂/血液 纤溶酶原灭活剂/血液 |
Effects of shuxuetong on acute coronary syndrome patients after interventional thearpy |
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Affiliation: | PLA 94 Hospital (Nanchang 330002) Song Jingchun Hang Guoming Ding Zhongru et al |
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Abstract: | Objective: To investigate the effects of shuxuetong on endothelial function and fibrinolysis activities of acute coronary syndrome(ACS) patients after interventional therapy and its early heart complication. Methods: t-PA, PAI-I and vWF were measured in 50 patients in therapy group and 34 patients of control group. Results: The levels of serum PAII and vWF in therapy group were lower, and the level of serum t PA was higher compared with that control group (P〈0. 05). The rate of early heart complication of therapy group was lower compared with in control group(P〈0.05). Conclusion: Shuxuetong can improve the endothelia function and fibrinolysis activities, and decrease the rate of early heart complication in ACS patients after interventional therapy. |
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Keywords: | Coronary disease/therapy @PCI @Endothelial function Plasminogen activators/blood Plasminogen inactivators/blood |
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