中西药联用防治500例血友病出血的临床研究

目的 研究中药止血煎剂联合西药止血合剂防治血友病出血的效果及其安全性。

Clinical Study of Combination of Chinese Medicine and Western Medicine in Treatment of 500 Patients with Hemophilia Hemorrhage

Objective To study the effect and safety of haemostatic apozem combined with haemostatic mixture on hemophilia hemorrhage.Methods Five hundred hemophilia patients were randomly recruited from Shaanxi Yida Hematology Institute from February 2005 to July 2010.Under the condition of using no blood products such as platelet cofactors Ⅷ and Ⅸ,oral administration of haemostatic apozem combined with intravenous dripping of haemostatic mixture were given to 332 hemorrhagic patients and 451 patients in need of surgery for hemorrhagia prevention.The treatment was lasted for three successive weeks.The hemostatic time,hemorrhage absorption（recovery） time,and their safety were observed.Results The hemostatic time for open bleeding and closed bleeding was（0.85± 0.83） h and（2.69±0.65） h respectively.The average hemostatic time was（2.00±0.69） h.The recovery time for different portions was as follows respectively：intra-cranial hemorrhage（14.13±6.01） days;muscular hemorrhage（18.18±7.34） days;hematuria（8.25±4.69） days;arthrorrhage（3.27±1.31） days;ecchymoma（7.16±2.32） days;bleeding of oral and nasal cavities（4.26±1.35） days;intramedullary hemorrhage（19.15±1.36） days;hematoma ulceration（50.01±20.91） days.The hemorrhage recovery ratio was 99.10%（329/332）.The success rate of preventing from surgery hemorrhage was 100%（451/451）.No severe adverse reaction occurred during the therapeutic course.Conclusions Haemostatic apozem combined with haemostatic mixture was effective and fast in preventing and treating hemophilia hemorrhage,with no complications or adverse reactions.It could be taken as the first choice for prevention and treatment of hemophilia hemorrhage.