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| 海藻多糖对类风湿关节炎成纤维样滑膜细胞凋亡的影响及机制研究 | |
| 引用本文： | 朱浪静,郑东辉,张白玉,闻克威,莫颖倩,李婷,高璇,戴冽. 海藻多糖对类风湿关节炎成纤维样滑膜细胞凋亡的影响及机制研究[J]. 中国中西医结合杂志, 2011, 31(7): 961-966 |
| 作者姓名： | 朱浪静 郑东辉 张白玉 闻克威 莫颖倩 李婷 高璇 戴冽 |
| 作者单位： | 1. 中山大学孙逸仙纪念医院风湿免疫科,广州,510120 2. 中山大学孙逸仙纪念医院风湿免疫科,广州,510120;广州医学院第三附属医院血液风湿科,广州,510150 3. 中国科学院南海海洋研究所,广州,510301 |
| 基金项目： | 国家自然科学基金面上项目，广东省科技计划项目，中国科学院海洋生物资源可持续利用重点实验室(LMB)开放基金 |
| 摘 要： | 目的 探讨海藻多糖对体外培养的类风湿关节炎(rheumatoid arthritis，RA)成纤维样滑膜细胞(fibroblast-like synovialcytes，FLS)凋亡的影响及机制。 |
| 关 键 词： | 类风湿关节炎；成纤维样滑膜细胞；海藻多糖；凋亡 |
Effect and Related Mechanism of Seaweed Polysaccharide on Apoptosis of Fibroblast-like Synoviocytes in Patients with Rheumatoid Arthritis |
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| ZHU Lang-jing,LI Ting and DAI Lie. Effect and Related Mechanism of Seaweed Polysaccharide on Apoptosis of Fibroblast-like Synoviocytes in Patients with Rheumatoid Arthritis[J]. Chinese journal of integrated traditional and Western medicine, 2011, 31(7): 961-966 | |
| Authors: | ZHU Lang-jing LI Ting DAI Lie |
| Affiliation: | DAI Lie,LI Ting,ZHU Lang-jing,et al Department of Rheumatology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou(510120) |
| Abstract: | Objective To study the effect and related mechanism of seaweed polysaccharide(SP) on apoptosis of fibroblast-like synoviocytes in patients with rheumatoid arthritis(RA-FLS).Methods RA-FLS were in vitro cultured using modified tissue culture method.Effect of SP(0,15,20,and 25 mg/mL,respectively) at different time points(0,3,4,and 5 days,respectively) on the proliferation and apoptosis of RA-FLS,and protein expressions of Caspase-3,Bax,and Bcl-2 was detected by cell counting kit-8(CCK-8) assay,Hoechst 33258 s... |
| Keywords: | rheumatoid arthritis fibroblast-like synoviocyte seaweed polysaccharide apoptosis |
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