浙江省赛罗群钩端螺旋体病的监测

目的研究赛罗群钩体病流行规律。方法用显微镜凝集试验法检测患者、水鸭和蛙血清抗体；同时分离培养病原体。用夹夜法捕鼠，采集鼠。肾、猪肾、牛中段尿、蛙肾、水鸭肾和蚂蟥血分离培养病原体。结果浙江省20世纪60至80年代钩体病不断出现大规模暴发流行，90年代后疫情平稳下降。到2004年为止，全省共发生钩体病138526例，死亡933例，年平均发病率为5.86／10万，病死率为0、67％。1997至2004年全省共发生钩体病956例，平均发病率为0、27/10万，死亡14例，平均病死率为1、46％。衢州、丽水和台州市的发病数占全省发病总数的93、20％。病例主要分布在7～10月份，占94．87％。患者血清抗体阳性率为61、72％，菌群主要为黄疸出血群、七日热群和赛罗群。患者血培养阳性率为1．0％。鼠密度为4．54％，以黑线姬鼠为优势种，占52．04％。鼠带菌率为3．82％，黑线姬鼠带菌率为6、05％。蛙。肾阳性率为0.41％。水鸭血清抗体阳性率为34％，菌株主要为秋季群和赛罗群；蛙血抗体阳性率为8．7％，菌株为秋季群。结论浙江省存在赛罗群钩体感染，钩体病进入低发期，需要科学监测。

Surveillance and study on the sejroe serogroup leptospirosis in Zhejiang province

Objective To investigate the serogroup change of Leptospirosis in Zhejiang prov- ince.Methods MAT method was used to test the serum antibody in patients,ducks and frogs.Lep- tospira was isolated by culture of the serum from patients,ducks and frogs as well as kidneys from pig,frog and duck,urine from cattle and mouse.Results Leptospirosis frequently outbroke during 1960s to 1980s.Its incidence has been decreased since 1990s.There were 138 526 patients in Zhejiang province from 1952 to 2004,933 of them died.The average incidence is 5.86 per 100 000.From 1997 to 2004 the total patients in the whole province are 956.The average incidence is 0.27 per 100 000, 14 of them died.Most of the patients located in Quzhou.Lishui and Taizhou city.The positive rate of serum antibody in patients,frogs and ducks are 61.72%,8.7% and 34%,respectively.The culture positive rate of patient's blood,mouse's kidney,frog's kidney were 1.0%,3.82% and 0.41%,re- spectively.Sejroe serogroup leptospira antibody was identified in the blood from patients and duck. Conclusion The infection of Sajroe serogroup leptospira exists in Zhejiang province.However,the in- cidence of Leptospirosis in Zhejiang province is very low currently.