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Deoxycorticosterone-secreting adrenocortical carcinoma |
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| Authors: | Akihiro Yamamoto Takushi Naroda Susumu Kagawa Yoshihumi Umaki Yasumi Shintani Toshiaki Sano Hironobu Sasano |
| Affiliation: | 1. Department of Urology, School of Medicine, The University of Tokushima, Tokushima 3. First Department of Internal Medicine, School of Medicine, The University of Tokushima, Tokushima 4. First Department of Pathology, School of Medicine, The University of Tokushima, Tokushima 5. Second Department of Pathology, Tohoku University, School of Medicine, Sendai, Japan |
| Abstract: | A case of DOC-secreting adrenocortical carcinoma in a 66-year-old man is reported. He had hypertension, hypokalemia, suppressed PRA, and excessive serum levels of DOC. His serum aldosterone level was normal. The resected adrenal mass weighed 230 g. Histologically, the tumor was mainly composed of compact cells associated with necrosis and atypical mitoses. Invasion of venous structure, sinusoids, and capsule was also present. Immunohistochemically, P450 C21 (21 -hydroxylase) was positive in many tumor cells, and P450 C17(17 α-hydroxylase) was intensely positive in a relatively small number of tumor cells. The patient died 9 months after operation due to rupture of metastatic liver tumor.Endocr Pathol 4:165–168, 1993. |
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