Constant region IgG allotypes in hares: Group e allelic polymorphism

Alloantisera prepared against domestic rabbit IgG allotypes were used in hemagglutination-inhibition and direct radioimmune binding tests to detect the Cγ region allotypes in hares from several geographical locations. The d11, d12 and e14 allotypes were absent in all the hare samples tested. The hemagglutination-inhibition and the radioimmune binding tests gave differing results in the classification of hares with respect to the e15 allotype. The apparent enigma was resolved by taking into consideration the concept of multiple antigenic determinants comprising the e15 allotypic system. The results are presented and discussed in terms of possible allelic genetic variants of the Cγ gene in hares.