microRNA在结直肠癌转移中作用机制的研究进展

 肿瘤细胞转移是由多种因子参与的复杂生物学行为,microRNA(miRNA)作为其中的重要因子,参与转移过程中的调控。结直肠癌患者中,转移引起的并发症是其主要死因。miRNA在结直肠癌转移中作用的研究目前尚处于起步阶段,目前已知其参与抗凋亡、上皮细胞间质化、瘤细胞增值侵袭及新生血管生成等步骤的调控,发挥促进或抑制结直肠癌细胞转移效应。本文就近年miRNA在结直肠癌的转移各通路中的作用与机制的研究进展进行综述,旨在就miRNA在临床诊断治疗的科研提供依据与思路。

Advancement in the study of mechanism of microRNA in metastasis of colorectal cancer

The metastasis of tumor cells is a pathological process that comprises multiple factors.microRNA is one of the important parts taking part in the regulation of the process.Complication of metastasis is the major cause of death in colorectal cancer (CRC).Nowadays research of microRNA in metastisis of CRC still remains inefficient and anti apoptotis,epithelial mesenchymal transition,gain of invation as well as angiogenesis is known to be the major regulation method,positive or negative.This review explores recent development in the role of microRNA and its mechanism of CRC metastases which may provide new insights that could be of therapeutic consequence.