An intracellular antigen that reacts with MO2, a monoclonal antibody to CD14, is expressed by human lymphocytes |
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Authors: | Tartakovsky Boris Fried Mordechai Bleiberg Margalit Turner Dan Hoffman Michael Yust Israel |
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Institution: | Research Unit, Clinical Immunology and AIDS Center, Tel Aviv Sourasky Medical Center, 6 Weizmann Str., 64239, Tel Aviv, Israel. b.tartakovsky@medscape.com |
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Abstract: | CD14, a lipopolysaccharide (LPS) receptor, is present on the surface membrane of phagocytic leukocytes; it is also present in a soluble form in serum. Recently published results confer to this molecule novel functions that are linked to T-cell activation and to apoptosis. We report here that we have defined and characterized a novel lymphocyte population in human peripheral blood, a population that expresses an intracellular antigen detectable with MO2, a monoclonal antibody directed against the human CD14 molecule. This population is composed primarily of CD8-positive T-cells. We found surprisingly that this novel MO2-positive population of lymphocytes was greatly enhanced in asymptomatic, untreated HIV-positive individuals. |
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