Tetrahydrobiopterin synthesis inhibitors induce nitric oxide synthesis in rat aorta |
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| Affiliation: | 1. Department of Neuro-Sensory Physiology, University Medical Center Göttingen, 37073 Göttingen, Germany;2. Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA;1. Swiss-Prot group, SIB Swiss Institute of Bioinformatics, 1 Rue Michel-Servet, 1211 Genève, Switzerland;2. Molecular Biology Department, Faculty of Science, Radboud University, PO box 9101, 6500HB Nijmegen, the Netherlands;3. Functional Gene Annotation, Preclinical and Fundamental Science, UCL Institute of Cardiovascular Science, University College London, London, UK;4. Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway;5. Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway;6. Division of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA |
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| Abstract: | ![]()
I. Incubation of rato aortic rings with tetrahydrobiopterin synthesis inhibitors (NAS or DAHP) significantly decreased contractions to phenylephrine. These two compounds significantly potentiated the vascular hyporeactivity induced by endotoxin. Inhibitors of nitric oxide synthesis (NLA or MLA) restored the contractile responses to this α1-agonist in NAS- or DAHP-treated control rings and abolished the NAS- or DAHP-induced increased hyporeactivity to PE in endotoxin-treated aortic rings. These observations suggest that treatment of isolated blood vessels with BH4 synthesis inhibitors induces the production of NO' synthesis, resulting in turn in a vascular hyporeactivity to PE potentiated in endotoxin-treated preparations. |
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