Microsomal and peroxisomal fatty acid oxidation in bile duct ligated rats: A comparative study between liver and kidney |
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| Affiliation: | 1. Research Centre for Infectious Diseases, Institute for Molecular Infection Biology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany;2. Department of General Visceral Vascular and Paediatric Surgery, University Hospital of Würzburg, Würzburg, Germany;3. Institute of Pathology, Julius-Maximilians-Universität Würzburg and Comprehensive Cancer Center Mainfranken, Würzburg, Germany;4. Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong;5. The Jockey Club Centre for Clinical Innovation and Discovery, LKS Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong;6. Paul-Klein-Centre for Immune Intervention, Cell Biology Unit, JGU, University Medical Centre, Mainz, Germany |
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| Abstract: | ![]()
- 1.1. Microsomal cytochrome P-450 and peroxisomal fatty acid oxidation was studied in the kidney of rats 7 days after bile duct ligation (BDL) and a comparative study between kidney and liver was done.
- 2.2. Only in the liver did cholestasis decrease the cytocrome P-450 content and the peroxisomal fatty acid (3-oxidation, the catalase activity, and the microsomal metabolism of lauric acid and aminopyrine.
- 3.3. In contrast, cholestasis did not influence these activities in the kidney. The microsomal and peroxisomal activities studied responded in a coordinate way to cholestasis.
- 4.4. These results could suggest the possibility of a cause-and-effect relationship between microsomal cytochrome P-450 and peroxisomal activity.
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