Sematilide blocks the inward rectifier potassium channel in isolated guinea pig ventricular myocytes |
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| Affiliation: | 1. Laboratory of Biochemical Neuropharmacology, Kazan Federal University, Kazan, Russian Federation;2. Eppley Institute, University of Nebraska Medical Center, Omaha NE, USA;1. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;2. Department of Physiology, Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;3. Physiology Research Center, Alimentary Tract Research Center, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;4. Department of Anatomical Sciences, School of Medicine, Medical Basic Sciences Research Institute, Cellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;1. Department of Biotechnology and Genetic Engineering, Faculty of Applied Science and Technology, Islamic University, Kushtia, 7003, Bangladesh;2. Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong;1. Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, China;2. Department of Orthopedics, Wuxi Ninth People''s Hospital Affiliated to Soochow University, Wuxi, Jiangsu, China;3. Department of Pathology, The Second Affiliated Hospital of Soochow University, Suzhou, China |
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| Abstract: | ![]()
- 1.1. In whole-cell patch recording, the relative potency of the blocking action of sematilide on IK1 was found to be constant at each potential level of IK1 activation. Under more acidic condition, the degree of block was decreased. These results strongly suggested that the neutral form of sematilide may penetrate the cardiac cell membrane via hydrophobic pathway.
- 2.2. In cell-attached patches, sematilide prolonged the interburst interval and reduced the opening probabilities of the IK1 channel without affecting either the mean open time or the mean closed time within a burst.
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