| Magnolol and 5-fluorouracil synergy inhibition of metastasis of cervical cancer cells by targeting PI3K/AKT/mTOR and EMT pathwaysOA |
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| 作者姓名： | Yuanyuan Chen Shanshan Chen Kaiting Chen Lanfang Ji Shuna Cui |
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| 作者单位： | 1. Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Medical College of Yangzhou University;2. Department of Gynecology and Obstetrics, Affiliated Hospital of Yangzhou University |
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| 基金项目： | Jiangsu Province Traditional Chinese Medicine Science and Technology Project (No. 2020ZX21);;Jiangsu Qinglian Project (2022); |
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| 摘 要： | Objective: This study is designed to investigate the mode of action of the synergistic effect of 5-fluorouracil(5-FU) and magnolol against cervical cancer.Methods: Network pharmacological approach was applied to predict the molecular mechanism of 5-FU combined with magnolol against cervical cancer. CCK-8 assay, colony formation assay, immunofluorescence staining, adhesion assay, wound healing mobility assay, cell migration and invasion assay and Western blot analysis were conducted to validate t...
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