首页 | 本学科首页   官方微博 | 高级检索  
     


Microsomal and peroxisomal fatty acid oxidation in streptozotocin diabetic rat liver
Affiliation:1. Cardiovascular Health Across the Lifespan (CHAL) Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada;2. Metabolic Disorders and Complications (MEDIC) Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada;3. Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom;4. Leeds Institute of Medical Research, St James''s University Hospital, Leeds, United Kingdom;5. MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom;6. Division of Medical Sciences, University of Oxford, Oxford, United Kingdom;7. Department of Medicine, McGill University Health Centre, CHAL Research Program, Montreal, Canada;8. Department of Medicine, McGill University Health Centre, Cancer Research Program, Montreal, Canada;9. Department of Biochemistry, McGill University, Montreal, Quebec, Canada;10. Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom;11. Department of Clinical Neuroscience for Children, Oslo University Hospital, Oslo, Norway;12. Medical and Developmental Genetics, Medical Research Council Human Genetics Unit, Edinburgh, United Kingdom;13. Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom;14. Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany;15. Cancer Research United Kingdom Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom;16. Firefinch Software Ltd, Edinburgh, United Kingdom;17. Cancer Research Program (CRP), Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada;1. Centre for Cell and Developmental Biology and State Key Laboratory of Agrobiotechnology, School of Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China;1. Department of Plant Biochemistry and Infection Biology, Biocentre Klein Flottbek, University of Hamburg, D-22609 Hamburg, Germany;2. Centre for Organelle Research, Faculty of Science and Technology, University of Stavanger, N-4036 Stavanger, Norway;3. Department of BioSciences, Rice University, Houston, TX 77005, USA;1. Key Laboratory of Plant Development and Environmental Adaption Biology, Ministry of Education, School of Life Science, Shandong University, Qingdao, 266237, China;2. Shandong Key Laboratory of Greenhouse Vegetable Biology, Institute of Vegetables and Flowers, Shandong Academy of Agricultural Sciences, Jinan, 250100, China;1. Division of Endocrinology, Metabolism & Lipid Research, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
Abstract:
Microsomal lauric acid hydroxylation and fatty acid peroxisomal β-oxidation were studied in hepatic subcellulant preparations from streptozotocin-induced diabetic and diabetic insulin-treated rats.
  • 1.2. The liver microsomes of the streptozotocin diabetic rats displayed a similar activity to hydroxylate lauric acid as the control microsomes.
  • 2.3. Diabetic insulin-treated rats showed lower (ω1) and ω-lauric acid hydroxylase activities than diabetic and control rats.
  • 3.4. Streptozotocin-induced diabetes and diabetic insulin-treated rats exhibited no significant changes on peroxisomal palmitoyl CoA β-oxidation compared to the control rats.
  • 4.5. Both microsomal and peroxisomal fatty acid oxidation responded in a similar way in this model of experimental diabetes.
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号