亚低温治疗急性脑出血的临床疗效及对自由基含量的影响

目的:本研究观察亚低温(MHT)技术治疗急性脑出血的临床疗效和对自由基含量的影响。方法:随机将52例急性脑出血病人分为治疗组和对照组各26例,治疗组在药物治疗脑出血的同时加用MHT治疗技术,并在治疗前及治疗后14天进行神经功能缺损评分及血清超氧化物歧化酶(SOD)、丙二醛(MDA)含量的测定。结果:治疗组较对照组神经功能缺损评分明显降低(P<0.05),血清SOD活性显著提高,MDA水平明显降低(P<0.01)。结论:MHT治疗技术可以明显改善急性脑出血患者的神经功能,与其清除自由基有一定关系。

Effect of Clinical Founction and the Serum Content of Free Radicals of Mild Hypothermia Therapy on Acute lntracerebrai Hemorrhage

Objective:To observe the clinical effects and the serum content of free radicals of mild hypothermia therapy (MHT) on acute intracerebral hemorrhage. Methods: 52 patients were randomly divided into the treatment group (26eases) and the control group (26 cases). Drugs were used in both groups,and mild hypothermia was only applied in the treatment group. The nereve function deficiency scores and the serum activity of superoxide dismutase(SOD) and content of malondindehyde(MDA) were compared before and after treatmem. Results: The nereve function deficiency scores of treatment group were obviously lower than those of control group(P<0. 05). The serum activity of SOD of treatment group was markedly higher than that of control group(P<0. 01). The serum contment of MDA of treatment group was significantly lower than that of control group(P<0. 01). Conclusions: Mild hypothermia therapy can obviously improve the nereve function of patients with acute Intracerebral Hemorrhage. It is related to eliminating free ridicals.