心脏型脂肪酸结合蛋白在急诊胸痛患者中的诊断价值

目的]探讨心脏型脂肪酸结合蛋白(H - FABP)在急诊胸痛患者中的诊断价值.方法]筛选急诊胸痛患者128例(0～6 h),立即采用H- FABP快速诊断试纸进行定性检测,同时测定血浆肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)、超敏C反应蛋白(hs - CRP)水平,计算各项指标单独及联合检测在诊断急性心...

Diagnostic value of heart-type fatty acid-binding protein in patients with acute chest pain

Objective] To investigate the value of heart-type fatty acid binding protein(H-FABP) in patients with acute chest pain.Methods] One hundred and twenty-eight patients within six hours after the onset of chest pain were selected.A qualitative detection of H-FABP was performed instantly using rapid test kit,The plasma levels of cardiac troponin I(cTnI),creatine kinase isoenzyme-MB(CK-MB) and high sensitive C-reactive protein(hs-CRP) were detected simultaneously.The sensitivity and specificity in diagnosis of acute myocardial infarction(AMI) were calculated.Results] Among 128 selected patients,68 had a final diagnosis of AMI.The sensitivities of H-FABP,cTnI,CK-MB and hs-CRP in diagnosis of AMI were 88.23%,44.12%,41.18% and 42.65% respectively within six hours,and the sensitivity of H-FABP was significantly higher than that of others(P<0.05).The specificities of H-FABP,cTnI,CK-MB and hs-CRP were 83.33%,93.30%,86.67% and 86.70% respectively.The specificity of H-FABP compared with others that was not statistically significant(P>0.05) within 6 hours.The sensitivity(92.64%),specificity(91.60%),positive value(98.00%) and negative value(90.00%) of combined H-FABP,cTnI,CK-MB and hs-CRP were the highest within 0-6 hours.Conclusion] Heart-type fatty acid binding protein is the most sensitive indicator for early AMI(within 6 hours) diagnosis and has very important application value for clinical diagnosis.The combination determination of multiple-index can improve efficiency of AMI diagnosis.