Healing,Inflammation, and Fibrosis: When Benign Becomes Cancer: Malignant Degeneration of Chronic Inflammation |
| |
| Authors: | Christopher Conlon Lauren Pupa Edward M. Reece Carrie K. Chu Jessie Z. Yu Joshua Vorstenbosch Sebastian Winocour |
| |
| Affiliation: | 1.Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas;2.School of Medicine, Baylor College of Medicine, Houston, Texas;3.Division of Plastic Surgery, Texas Children''s Hospital, Houston, Texas;4.Department of Plastic Surgery, MD Anderson Cancer Center, University of Texas, Houston, Texas;5.Division of Plastic Surgery, McGill University, Montreal, Canada |
| |
| Abstract: | ![]()
Chronic inflammation, long implicated in the genesis of malignancy, is now understood to underlie an estimated 25% of all cancers. The most pertinent malignancies, to the plastic surgeon, associated with the degeneration of chronic inflammation include Marjolin''s ulcer, breast implant-associated large cell lymphoma, radiation-induced sarcoma, and Kaposi''s sarcoma. The cellular and genetic damage incurred by a prolonged inflammatory reaction is controlled by an increasingly understood cytokinetic system. Advances in understanding the chronic inflammatory cascade have yielded new therapeutics and therapeutic targets. |
| |
| Keywords: | chronic inflammation malignant degeneration Marjolin''s ulcer BI-ALCL radiation-induced sarcoma Kaposi''s sarcoma |
|
|
