视网膜色素变性黄斑区视网膜FD-OCT及mfERG观察

目的　利用频域光学相干断层扫描（ｆｒｅｑｕｅｎｃｙｄｏｍａｉｎｏｐｔｉｃａｌｃｏｈｅｒｅｎｃｅｔｏｍｏｇｒａｐｈｙ，ＦＤ-ＯＣＴ）及多焦视网膜电图（ｍｕｌｔｉ-ｆｏｃａｌｅｌｅｃｔｒｏｒｅｔｉｎｏｒｇｒａｍ，ｍｆＥＲＧ）观察视网膜色素变性（ｒｅｔｉｎｉｔｉｓｐｉｇｍｅｎｔｏｓａ，ＲＰ）患者黄斑区视网膜图像特征。方法　选取临床确诊的ＲＰ患者３０例（３０眼）作为ＲＰ组，年龄相匹配的健康人３０人（３０眼）作为对照组。采用ＦＤ-ＯＣＴＲＴＶｕｅ的Ｅ-ＭＭ５扫描模式对５ｍｍ×５ｍｍ范围的黄斑中心视网膜进行检测，获取视网膜厚度及内、外层视网膜容积，同时采用ＲＥＴＩｐｏｒｔ视觉电生理系统测量ｍｆＥＲＧ，对两组测量结果进行比较分析。结果　ＲＰ组视网膜黄斑中心凹厚度为（１４０．８０±１９．２５）μｍ，对照组为（１６５．９１±１４．３９）μｍ，差异无统计学意义（Ｐ＞０．０５）。ＲＰ组黄斑区外层视网膜体积为（３．６１±０．１８）ｍｍ３，低于对照组（４．５９±０．１１）ｍｍ３，差异有显著统计学意义（Ｐ＜０．００１）。ＲＰ组黄斑区内层视网膜体积为（２．２８±０．１０）ｍｍ３，对照组为（２．３０±０．１０）ｍｍ３，两组比较差异无统计学意义（Ｐ＞０．０５）。ＲＰ组ｍｆＥＲＧ各环Ｎ１、Ｐ１波反应密度值均低于对照组，且差异均有统计学意义（均为Ｐ＜０．０５）。ＲＰ组Ｎ１、Ｐ１波３～５环的潜伏期较对照组显著延长，差异均有统计学意义（均为Ｐ＜０．０５）。结论　ＦＤ-ＯＣＴ和ｍｆＥＲＧ相结合可有效评价ＲＰ患者视网膜功能及形态特点。

Observation of macular retina using frequency domain optical coherence tomography and multifocal electroretinogram in retinitis pigmentosa

Objective To assess the features of macular retina in subjects with retinitis pigmentosa ( RP) by frequency domain optical coherence tomography ( FDOCT) and multifocal electroretinogram ( mfERG) . Methods Thirty patients ( 30 eyes) with RP were set as RP group , and 30 age-matched healthy volunteers ( 30 eyes) as control group. A1l subjects underwent FD-OCT RTVue , the macular central retina within 5 mm x 5 mm was exanuned by E-MM5 scanning mode , the retinal thickness and inner. outer retinal volume were obtained.the mfERG was also performed by RETIport, and the data was analyzed with software SPSS. Results There was no difference in the retinal thickness between the RP group ( 140. 80 + 19. 25 ) ym and control group ( 165 . 91 + 14. 39) ym (P > 0. 05 ) . The outer macular volume in the RP group (3. 61 + 0. 18) mm3 was significantly lower than that in the control group (4. 59 + 0. 11 ) mm3 (P < 0. 001) . There was no difference in the inner macular volume between the RP group (2. 28 + 0. 10) mm3 and control group ( 2. 30 + 0. 10 ) mm3 ( P > 0. 05 ) . The response densities of N1 and Pl wave in each ring of mfERG in RP group were lower than those in control group ( all P < 0. 05) . While the latencies of Nl and Pl wave in ring 3 , ring 4 and ring 5 in RP group were significantly longer than those in control group ( all P < 0. 05). Conclusion Combined FD-OCT and mfERG together to examine RP patients can provide us more information about the macular structure and function changes.