妊娠期肝内胆汁淤积症与围生儿结局关系的研究进展

妊娠期肝内胆汁淤积症(ICP)是中、晚孕期常见的特发性肝脏功能紊乱性疾病。该病以皮肤瘙痒及血清总胆汁酸(TBA)水平升高为典型临床特征。我国部分地区的ICP发病率远高于欧美国家。ICP孕妇一般预后良好，但ICP对围生儿常危害严重，可引起早产、胎儿宫内窘迫、新生儿窒息、羊水胎粪污染甚至胎死宫内等。目前，多数学者认为围生儿不良结局与孕妇血清TBA水平有密切关系，但ICP导致不同妊娠结局的病理机制尚未完全阐明。笔者现从血清TBA异常升高对母儿影响的角度，对ICP与围生儿结局关系的研究进展进行综述。

Research progress of relationship between intrahepatic cholestasis of pregnancy and perinatal infants

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease mainly during the third trimester.It could be characterized by maternal pruritus and raised serum total bile acids (TBA). The ICP incidences in some areas of China are much higher than that of Europe and North America.The pregnant women with ICP usually have good prognosis.But for perinatal infants, ICP is a potential harm, it can course preterm delivery, fetal distress, neonatal asphyxia, meconium-stained amniotic fluid and stillbirth and so on. At present, most scholars believe that the high level of serum TBA in pregnant woman with ICP have strong relationship with adverse perinatal outcomes, but the mechanism has not been fully elucidated. In this paper, the relationships between ICP and perinatal outcomes are summarized.