慢性丙型肝炎患者干扰素治疗前后黄斑中心凹下脉络膜厚度的研究

目的 利用相干光断层扫描仪深度增强成像（EDI-OCT）模式分析慢性丙型肝炎干扰素治疗前后脉络膜厚度的变化。设计 回顾性病例系列。 研究对象 北京地坛医院干扰素治疗的平均年龄（43.7±10.5）岁的HCV患者11例（22眼）。方法 在接受干扰素治疗前及治疗后3个月行矫正视力、眼压、裂隙灯显微镜、散瞳间接检眼镜、眼底彩色照相及用海德堡SPECTRALIS-OCT深度增强成像模式检查。主要指标 黄斑中心凹下脉络膜厚度（SFCT）。结果 11例患者中6例9眼出现干扰素相关性视网膜病变。22眼治疗前SFCT（317.6±78.8）μm和治疗后（280.1±77.1）μm有明显统计学差异（P=0.000）。出现视网膜病变的眼（9眼）与未出现视网膜病变的眼（13眼）干扰素治疗后SFCT分别为（320.5±82.4）μm和（252.1±61.7）μm（P=0.053）。结论 慢性丙型肝炎患者干扰素治疗后SFCT有变薄的趋势。（眼科， 2014， 23： 240-243）

Changes in subfoveal choroidal thickness after interferon therapy in chronic hepatitis C patients

Objective To evaluate changes in choroidal thickness as measured by enhanced depth imaging spectral -domain optical coherence tomography (EDI-OCT) after interferon therapy in chronic hepatitis C patients. Design Retrospective case series. Participants  11 cases (22 eyes) of chronic hepatitis C patients (43.7±10.5 year-old) with interferon therapy from Beijing Ditan Hospital. Methods All the patients underwent detailed ocular examinations including corrected visual acuity, intraocular pressure, slit lamp microscope, indirect ophthalmoscope and color fundus photography. The subfoveal choroidal thickness (SFCT) was measured using EDI -OCT at baseline and 3 months after the treatment with interferon. Main Outcome Measures SFCT. Results Among 11 patients, 9 eyes (5.7%) of 6 cases developed interferon-related retinopathy.13 patients had bilateral retinopathy and 11 patients had unilateral retinopathy. SFCT of patients was (317.6±78.8) μm at the baseline and decreased to (280.1±77.1) μm after interferon therapy (P=0.000). There was no difference in SFCT between with retinopathy group (320.5±82.4) μm and without retinopathy group (252.1±61.7) μm (P=0.053). Conclusion There is an overall thinning of the SFCT on EDI OCT after interferon treatment in chronic hepatitis C patients. (Ophthalmol CHN, 2014, 23: 240-243)