电感耦合等离子体质谱法快速测定血液尿液中的铅和镉

目的:建立一种能同时测定血液尿液中铅和镉的方法。方法:用0.1%Triton X-100-0.5g/LED-TA-2%氨水混合溶液稀释血液和尿液,然后直接用电感耦合等离子质谱仪测定铅镉的含量。结果:铅镉的方法检出限分别为0.181μg/L和0.189μg/L,样品测定的精密度<6%,铅的回收率在92.2%～115.6%之间,镉的回收率在103.1%～107.2%之间。对冻干牛血(GBW09139g、GBW09130g)、冻干人尿铅(GBW09105e)、冻干人尿镉(ZK018-2)中铅和镉的含量进行了分析,测定值与标准参考值吻合。结论:本方法快速灵敏,精密度和准确度均符合要求,结果令人满意。

Determination of lead and cadmium in blood and urine by inductively coupled plasma mass spectrometry(ICP-MS)

Objective:To develop a method for routine analysis of lead and cadmium in whole blood and urine at the same time.Methods: Lead and cadmium in blood and urine was detected by ICP-MS directly after diluted by a solution of 0.1% Triton X-100,0.5 g/L EDTA and 2% ammonium hydroxide.Results: Detection limits were 0.181 μg/L for lead and 0.189 μg/L for cadmium.Standard deviations were below 6%.The recovery ratios were 92.2%～115.6% for lead and 103.1%～107.2% for cadmium.By the method,the analysis results of lead and cadmium levels in GBW09139g,GBW09130g,GBW09105e and ZK018-2 were consistent with the certified values.Conclusion: The method was simple,rapid,accurate and reliable.The analysis results were satisfactory.