Hepatic sinusoidal obstruction associated with S-1 plus cisplatin chemotherapy for highly advanced gastric cancer with paraaortic lymph node metastases: report of a case |
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| Authors: | Hirofumi Toi Yosuke Miura Susumu Shibasaki Kenji Chisaka Manabu Goto Ichiro Tsuda Takahisa Nakamura Taiji Hase |
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| Affiliation: | 1. Department of Surgery, Hokushinkai Megumino Hospital, 2-3-5 Megumino-Nishi, Eniwa, Hokkaido, 061-1395, Japan
2. Department of Gastroenterology, Hokushinkai Megumino Hospital, 2-3-5 Megumino-Nishi, Eniwa, Hokkaido, 061-1395, Japan
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| Abstract: | A 56-year-old man who was diagnosed with gastric cancer with multiple paraaortic lymph node metastases was treated with S-1 plus cisplatin. The spleen gradually enlarged during the therapeutic courses. After the 6th course of therapy, the primary gastric lesion and paraaortic lymphadenopathies disappeared. He underwent a curative resection, including a distal gastrectomy with regional and paraaortic lymph node dissections. Irregularly distributed congestion of the liver was noted during the surgery. Histological examinations revealed residual cancer cells in 3 regional lymph nodes and no cancer cells in the primary site and paraaortic lymph nodes. Hepatic sinusoidal obstruction syndrome (SOS) was also confirmed histologically. This is the first report of a case with SOS after S-1 plus cisplatin therapy. S-1 plus cisplatin therapy can cause SOS, although it is a promising preoperative chemotherapy for highly advanced gastric cancer. |
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