| 卡维地洛缓释片的制备及其释放度考察 |
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| 引用本文： | 吴卫,周娜. 卡维地洛缓释片的制备及其释放度考察[J]. 中南药学, 2012, 10(4): 261-263 |
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| 作者姓名： | 吴卫 周娜 |
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| 作者单位： | 1. 桂林医学院,广西桂林,541004
2. 广州市戒毒管理局医院,广州,510030 |
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| 摘 要： | 目的 制备卡维地洛缓释片并考察其体外释放度.方法 采用粉末直接压片法制备卡维地洛缓释片,紫外分光光度法测定卡维地洛的含量,考察其在体外的释放度.结果 所制备卡维地洛缓释片4h内药物累积释放量为40％左右,体外释放曲线拟合优度较好的方程为Higuchi方程,相关系数为r=0.993 7.结论 卡维地洛缓释片中药物释放具有明显的缓释效果.
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| 关 键 词： | 卡维地洛 缓释片 药物释放度 |
Preparation and drug release of carvedilol sustained-release tablets |
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| WU Wei , ZHOU Na. Preparation and drug release of carvedilol sustained-release tablets[J]. Central South Pharmacy, 2012, 10(4): 261-263 |
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| Authors: | WU Wei ZHOU Na |
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| Affiliation: | 1.Guilin Medical College,Guilin Guangxi 541004;2.Hospital of Guangzhou Bureau of Drug Rehabilitation,Guangzhou 510030) |
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| Abstract: | Objective To prepare carvedilol sustained-release tablets and inspect its in vitro drug release. Methods UV was used to determine the content of carvedilol and inspect its in vitro release. Results The drug release of carvedilol sustained-release tablets was about 40% after 4 h,and the release kinetics in vitro followed the Higuchi equation(r=0.993 7). Conclusion The release experiments in vitro show that carvedilol has obvious sustained-release effect. |
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| Keywords: | carvedilol sustained-release tablet drug release |
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